Table 3 Results of significant 1 allele substitution effects P-value
Trait | SNP2 | Estimate ± SE3 | P-values | FDR4 | ||
|---|---|---|---|---|---|---|
Fatty acid | Common name | Lab Id | rs# | P-values | ||
Polyunsaturated fatty acids | ||||||
C18:2n9c11t | CLA:9c11t | FADS2-19 | rs210169303 | -0.0176 ± 0.0083 | 0.036 | 0.248 |
C18:2n10t12c | CLA:10t12c | FADS2-19 | rs210169303 | -0.0012 ± 0.0005 | 0.010 | 0.069 |
C18:2n6cc | Linoleic acid | FADS1-07 | rs42187261 | -0.0410 ± 0.0197 | 0.038 | 0.137 |
FADS1-08 | rs41652284 | -0.0468 ± 0.0226 | 0.039 | 0.137 | ||
C18:2n6tt | Trans linoleic acid | FADS1-07 | rs42187261 | 0.0069 ± 0.0033 | 0.036 | 0.126 |
FADS2-19 | rs210169303 | -0.0083 ± 0.0034 | 0.016 | 0.109 | ||
C20:3n6 | Dihomogamma linolenic acid | FADS1-01 | rs136261927 | -0.0087 ± 0.0021 | 0.000 | 0.0004 |
FADS1-07 | rs42187261 | 0.0037 ± 0.0017 | 0.032 | 0.055 | ||
FADS1-08 | rs41652284 | -0.0044 ± 0.0020 | 0.027 | 0.055 | ||
FADS2-23 | rs109772589 | -0.0080 ± 0.0021 | 0.0002 | 0.001 | ||
C20:4n6 | Arachidonic acid | FADS1-07 | rs42187261 | 0.0042 ± 0.0016 | 0.009 | 0.032 |
FADS2-23 | rs109772589 | -0.0071 ± 0.0020 | 0.0004 | 0.003 | ||
C20:5n3 | Eicosapentaenoic acid | FADS1-07 | rs42187261 | 0.00420 ± 0.0008 | 0.0036 | 0.039 |
Monounsaturated fatty acids | ||||||
C14:1 t | Myristelaidic acid | FADS2-05 | rs211263660 | 0.0092 ± 0.0046 | 0.047 | 0.256 |
C18:1n9c | Oleic acid | FADS1-07 | rs42187261 | -0.7529 ± 0.2889 | 0.009 | 0.067 |
C18:1 total | FADS1-07 | rs42187261 | -0.7697 ± 0.3023 | 0.011 | 0.079 | |
Total MUFA | FADS1-07 | rs42187261 | -0.8044 ± 0.3445 | 0.020 | 0.141 | |
Saturated fatty acids | ||||||
C6:0 | Caproic acid | FADS1-07 | rs42187261 | 0.0215 ± 0.0110 | 0.050 | 0.353 |
C8:0 | Caprylic acid | FADS1-07 | rs42187261 | 0.0246 ± 0.0108 | 0.023 | 0.158 |
C10:0 | Caprinic acid | FADS1-07 | rs42187261 | 0.087 2 ± 0.0382 | 0.023 | 0.161 |
C11:0 | Undecanoic acid | FADS1-07 | rs42187261 | 0.0111 ± 0.0041 | 0.008 | 0.053 |
C12:0 | Lauric acid | FADS1-07 | rs42187261 | 0.1249 ± 0.0525 | 0.018 | 0.125 |
C16:0 | Palmitic acid | FADS1-01 | rs136261927 | 0.6519 ± 0.3287 | 0.048 | 0.084 |
FADS1-07 | rs42187261 | 0.5063 ± 0.2555 | 0.048 | 0.084 | ||
FADS2-05 | rs209202414 | -0.5908 ± 0.2473 | 0.017 | 0.079 | ||
FADS2-19 | rs210169303 | 0.6281 ± 0.2746 | 0.023 | 0.079 | ||
C23:0 | Tricosanoic acid | FADS1-07 | rs42187261 | 0.0021 ± 0.0008 | 0.006 | 0.044 |
Total SFA | FADS1-07 | rs42187261 | 0.8069 ± 0.3549 | 0.024 | 0.165 | |