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Table 1 Summary of clinical data on deafness in five Chinese pedigrees carrying a heteroplasmic A1555G mutation

From: Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation

Subject Gender Age Audiometric configuration Use of aminoglycosides Age at onset (y) PTA (dB) right ear PTA (dB) left ear Level of hearing impairment Heteroplasmy rate (%)
KM001-II-2 F 50 Slope Yes 1 76 70 Severe 93.47
KM001-II-4 F 45 Slope Yes Not known 40 51 Mild 91.02
KM001-II-6 F 43 Slope Yes Not known 41 41 Moderate 92.01
KM001-II-8 F 41 Slope Not known Not known 76 63 Moderate 93.25
KM001-II-10 F 39 Slope Not known Not known 40 39 Mild 95.05
KM001-II-13 M 36 Slope Yes Not known 54 60 Moderate 95.01
KM001-III-1 F 29 Slope Yes 1.5 74 74 Severe 94.16
KM001-III-3 F 23 Slope Yes 2 93 95 Profound 93.60
KM001-III-4 M 24 Slope Yes 1 95 93 Profound 93.13
KM001-III-5 F 22 Slope Yes Not known 43 54 Moderate 91.50
KM001-III-7 F 22 Slope Yes 12 50 70 Moderate 93.54
KM003-III-4 F 18 Slope Yes Not known 103 100 Profound 96.08
KM008-III-8 F 19 Slope Yes 2 104 109 Profound 66.76
KM009-II-5 F 44 Slope Yes Not known 98 76 Severe 94.24
KM009-III-3 M 20 Slope Yes Not known 98 95 Profound 94.92
KM011-III-7 M 35 Slope Yes 6 83 80 Severe 86.23
KM011-III-8 M 30 Flat Not known 20 59 68 Moderate 87.20
KM011-III-9 M 52 Slope Yes 3 100 100 Profound 83.58
KM011-III-11 F 45 Slope Yes Not known 51 55 Moderate 89.29
KM011-III-15 F 40 Flat Yes 3 110 110 Profound 82.32
KM011-III-17 F 37 Slope Yes 4 69 73 Moderate 85.19
KM011-IV-1 F 26 Slope Not known Not known 46 49 Moderate 85.87
KM011-IV-2 M 24 Slope Not known Not known 51 48 Moderate 91.14
KM011-IV-4 F 20 Slope Yes 2 109 103 Profound 87.48
KM011-IV-5 F 20 Slope Yes Not known 93 93 Profound 94.65
KM011-IV-10 F 20 Flat Yes 2 94 93 Profound 93.80