Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation

Table 2 Summary of genetic and molecular data for 5 Chinese families carrying the heteroplasmy A1555G mutation

Pedigree	Number of matrilineal relatives	Number of patients	Penetrance^a(%)	Generation	Number of generation	Heteroplasmy level^b(%)
Pedigree	Number of matrilineal relatives	Number of patients	Penetrance^a(%)	Generation	Number of generation	Min	Max	Generation mean	Pedigree mean
KM001	25	13	52	II	7	91.02	95.05	93.19	93.34
KM001	25	13	52	III	11	91.50	94.16	93.43	93.34
KM003	11	2	18.2	II	3	32.87	94.31	69.76	78.28
KM003	11	2	18.2	III	4	58.69	96.08	84.68	78.28
KM008	20	2	10	I	1	23.55	23.55	23.55	31.98
				II	5	0	43.79	26.63
				III	9	0	91.35	35.89
KM009	15	4	26.7	I	1	91.38	91.38	91.38	93.57
				II	3	92.21	94.24	93.41
				III	2	94.41	94.92	94.67
KM011	34	15	44.1	II	2	87.85	88.69	88.27	87.99
				III	12	82.32	90.89	86.78
				IV	6	85.87	94.65	90.31

ISSN: 2730-6844