Table 6 Results of functional annotation on KEGG pathway including genes 0.5 Mb flanking size to SNPs with p < 5.0 × 10 -5
Term | Pathway name | Number of involved genes | Involved genes | David p-value |
|---|---|---|---|---|
ssc05213 | Endometrial cancer | 5 | TCF7L2,ERK2, PTEN, PIK3R5. TP53 | 0.001 |
ssc04540 | Gap junction | 6 | TUBA4A, ERK2, ADRB1, PRKG1, TUBA3D, TUBA1A | 0.002 |
ssc04070 | Phosphatidylinositol signaling system | 4 | PTEN, PIK3R5, PLCD4, PI4KA | 0.013 |
ssc00562 | Inositol phosphate metabolism | 4 | PTEN, PIK3R5, PLCD4, PI4KA | 0.015 |
ssc05214 | Glioma | 4 | ERK2, PTEN, PIK3R5, TP53 | 0.026 |
ssc05215 | Prostate cancer | 5 | ERK2, PTEN, PIK3R5, TP53, TCF7L2 | 0.027 |
ssc04910 | Insulin signaling pathway | 5 | ERK2, SLC2A4, PIK3R5, PRKAR1A, PRKAG3 | 0.031 |
ssc05218 | Melanoma | 4 | ERK2, PTEN, PIK3R5. TP53 | 0.033 |