Genome-wide association studies for hematological traits in Chinese Sutai pigs

BMC Genomic Data

Table 2 Description of lead SNPs showing significant association with hematological traits by GWAS

Traits¹	Peak SNP	Num²	Chr³	Pos (bp)⁴	Nearest gene⁵	Distance (bp)⁶	P-value	Var (%)⁷
MCV^**	ss478944677	75	2	55226096	SH3BP5L	Within	3.00E-11	19.41
MCH^**	ss131190955	60	2	60227081	CPAMD8	Within	1.36E-10	7.91
RDW^**	ss107831331	14	2	70061497	CARM1	Within	2.10E-07	14.13
MCHC^*	ss131046473	22	6	49168322	ELSPBP1	65	1.52E-06	10.06
HCT^*	ss131276048	5	4	104825883	INTS3	Within	3.19E-06	6.80
RBC^*	ss131276048	4	4	104825883	INTS3	Within	3.78E-06	6.52
HGB^*	ss131493776	1	13	11696883	UBE2E1	Within	7.88E-06	4.75
WBC^*	ss107857076	2	2	105499649	ENSSSCG00000030166	95033	6.03E-06	8.66
P-LCR^**	ss107886044	17	2	56469735	TRIM58	Within	1.58E-07	13.32
MPV^*	ss107886044	5	2	56469735	TRIM58	Within	2.49E-06	15.43

The associated region was defined as the interval the distances between two adjacent genome-wide significant SNPs was less than 10 Mb.
¹The abbreviations of hematological traits are given in Table 1. e.g. MCV is Mean corpuscular volume.
²The number of significant SNPs for each hematological trait.
^{3, 4}Chromosomal locations and positions of the most significant SNP associated with hematological traits in Sus scrofa Build 10.2 assembly.
⁵The nearest annotated gene to the significant SNP. The annotated gene database is from http://asia.ensembl.org/index.html.
⁶SNP designated as in a gene or distance (bp) from a gene region in Sus scrofa Build 10.2 assembly, “0” in column 6 represent un-annotated genes.
⁷the phenotype variance explained by the significant SNP.
^**Genome-wide significant.
^*Chromosome-wide significant.

ISSN: 2730-6844