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Figure 4 | BMC Genetics

Figure 4

From: A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster

Figure 4

Misexpression of reduced-lifespan genes in specific tissues was responsible for reduced lifespan in adult flies. Misexpression of reduced-lifespan genes in specific tissues was responsible for reduced lifespan in adult flies. (A-D) Survival curves of adult flies misexpressing reduced-lifespan genes. Tissue-specific expression of reduced-lifespan genes in adult flies was induced with the TARGET system. Survivor rates were scored every three days. (A, B) Two representative reduced-lifespan genes (A) GS5065 (CG11819) and (B) GS10665 (High mobility group protein D) were misexpressed using various GAL4 drivers, indicated in the upper right. (C, D) Survival curves for all identified reduced-lifespan genes when driven by the GAL4 driver (C) 24B-GAL4 or (D) P{GawB}l(3)31-131–1. Blue lines: survival curve of a wild-type (Canton-S) control. Magenta lines: survival curves showing a lifespan less than 1/3 that of wild-type control flies; the corresponding reduced-lifespan genes are shown in the upper right. Survival curves showing a lifespan greater than 1/3 of that of wild-type control flies are shown in black; the corresponding gene names are not shown.

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