A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster

BMC Genomic Data

Table 2 Disease-related reduced-lifespan genes

Reduced-lifespan gene	Human ortholog	Homology (%)^a	Related diseases	Reference
dream	CASP9	28	Alzheimer’s disease, Cancer	ROHN and HEAD [23], DEVARAJAN et al. [24]
Hepatocyte nuclear factor 4	HNF4alpha	67	Diabetes	OMIM *600281
Calpain-A	CAPN3	39	Muscular dystrophy	OMIM *114240
embryonic lethal abnormal vision	ELAVL4	53	Cancer, Anti-Hu syndrome	SZABO et al. [25]
degringolade	RNF4	42	Cancer	HIRVONEN-SANTTI et al. [26], PERO et al. [27]
atlastin	ATL1	56	Spastic paraplegia	OMIM *606439
slipper	MLK2	50	Huntington’s disease	PHELAN et al. [28]
polo	PLK1	52	Cancer	STREBHARDT [29]
High mobility group protein D	SSRP1	52	Cancer	HUDSON et al. [30]
Fmr1	FXR1	49	Fragile X mental retardation	VERKERK et al. [31]
Peroxin 16	PEX16	36	Zellweger syndrome	OMIM *603360
Vacuolar H + ATPase subunit 100-2	ATP6V0A4	51	Distal renal tubular acidosis	OMIM *605239
roadkill	SPOP	79	Cancer	LIU et al. [32]
CG8290	ATRX	36	ATRX (Xlinked αthalassemia with mental retardation)	OMIM *300032
Lamin	LMNA	38	More than a dozen different inherited diseases, including progeria syndrome	OMIM *150330
Elongation factor Tu mitochondrial	TUFM	66	Combined oxidative phosphorylation deficiency	OMIM *602389
CG11819	UNC13D	23	Familial hemophagocytic lymphohistiocytosis-3	OMIM *608897
CG8032	SMOX	33	Cancer	BABBAR and CASERO [33], GOODWIN et al. [34], XU et al. [35]
N-methyl-D-aspartate receptor-associated protein	GRINA	46	Epilepsy	BONAGLIA et al. [36]
Src oncogene at 42A	FRK	61	Cancer	HOSOYA et al. [37]

^aamino acid identity (%) between reduced-lifespan genes and their human orthologs.

ISSN: 2730-6844