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Table 3 Stratified analysis of LAPTM4B gene polymorphism on cancer susceptibility

From: LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis

 

N

*2 vs. *1

*2/2 vs. *1/1

*2/1 vs. *1/1

*2/1 + *2/2 vs. *1/1

*2/2vs. *2/1 + *1/1

  

OR (95% CI)

p

PQ

OR (95% CI)

p

PQ

OR (95% CI)

p

PQ

OR (95% CI)

p

PQ

OR (95% CI)

p

PQ

Control source

HB

13

1.53 (1.36-1.73)

<0.001

0.002

2.33 (1.96-2.76)

<0.001

0.234

1.58 (1.36-1.84)

<0.001

0.007

1.67(1.52-1.83)

<0.001

0.001

1.86(1.58-2.19)

<0.001

0.612

PB

4

1.49 (1.06-2.092)

0.020

0.023

1.16 (0.35-3.80)

0.811

0.016

1.87 (1.40-2.49)

<0.001

0.247

1.72(1.09-2.72)

0.019

0.073

0.88(0.30-2.54)

0.806

0.029

Cancer type

Liver cancer

4

1.66 (1.43-1.94)

<0.001

0.714

2.15 (1.42-3.25)

<0.001

0.312

2.03 (1.61-2.57)

<0.001

0.847

2.06 (1.64-2.58)

<0.001

0.963

1.52 (1.02-2.24)

0.037

0.220

Lung cancer

2

1.24 (0.63-2.41)

0.534

0.013

1.13 (0.13-9.50)

0.912

0.003

1.59 (1.11-2.29)

0.012

0.268

1.49 (0.77-2.89)

0.234

0.058

0.90 (0.14-5.90)

0.915

0.007

Breast cancer

2

1.51 (1.09-2.11)

0.014

0.058

2.41 (0.97-6.01)

0.059

0.075

1.49 (1.23-1.81)

<0.001

0.187

1.55 (1.29-1.87)

<0.001

0.101

1.64 (1.13-2.38)

0.009

0.116

GC

3

1.81 (1.58-2.07)

<0.001

0.253

2.90 (2.16-3.90)

<0.001

0.638

1.89 (1.56-2.29)

<0.001

0.584

2.07 (1.73-2.48)

0.007

0.400

2.14 (1.62-2.84)

<0.001

0.716

GIC

4

1.26 (0.97-1.65)

0.084

0.008

1.49 (0.77-2.88)

0.236

0.024

1.33 (1.03-1.73)

0.030

0.084

1.36 (1.00-1.84)

0.050

0.020

1.32 (0.76-2.30)

0.331

0.069

Others

4

1.39 (1.01-1.92)

0.043

0.020

2.32 (1.56-3.46)

<0.001

0.257

1.26 (0.81-1.96)

0.316

0.020

1.39 (0.89-2.19)

0.150

0.011

2.10 (1.43-3.09)

<0.001

0.546

Histopathologic differentiation

  

poor

4

1.61 (0.96-2.70)

0.069

0.006

2.34 (0.64-8.59)

0.200

0.008

2.03 (1.10-3.75)

0.024

0.050

2.07 (1.05-4.12)

0.037

0.015

1.56 (0.62-3.95)

0.346

0.060

moderate

4

1.29 (0.96-1.72)

0.091

0.341

0.98 (0.44-2.20)

0.959

0.333

1.83 (1.23-2.74)

0.003

0.527

1.67 (1.13-2.47)

0.010

0.341

0.73 (0.33-1.59)

0.425

0.523

well

4

1.48 (0.88-2.50)

0.143

0.060

2.14 (0.53-8.60)

0.284

0.045

1.60 (1.00-2.55)

0.049

0.172

1.60 (1.03-2.50)

0.037

0.121

1.35 (0.67-2.73)

0.398

0.146

TNM stage

I-II

8

1.38 (1.04-1.84)

0.028

0.006

1.89 (0.89-4.00)

0.097

0.005

1.43 (1.16-1.77)

0.001

0.415

1.49 (1.22-1.82)

<0.001

0.096

1.61 (0.81-3.18)

0.175

0.008

III-IV

8

1.56 (1.31-1.87)

<0.001

0.032

2.23 (1.67-2.98)

<0.001

0.075

1.79 (1.40-2.28)

<0.001

0.047

1.86 (1.44-2.40)

<0.001

0.017

1.70 (1.29-2.23)

<0.001

0.276

  1. OR odds ratio, 95% CI 95% confidence interval, P Q p value for heterogeneity, HB hospital-based, PB population-based, GC Gynecological cancer, GIC Gastrointestinal cancer, TNM Tumor, Node, Metastasis.