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Table 3 Stratified analysis of LAPTM4B gene polymorphism on cancer susceptibility

From: LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis

  N *2 vs. *1 *2/2 vs. *1/1 *2/1 vs. *1/1 *2/1 + *2/2 vs. *1/1 *2/2vs. *2/1 + *1/1
   OR (95% CI) p PQ OR (95% CI) p PQ OR (95% CI) p PQ OR (95% CI) p PQ OR (95% CI) p PQ
Control source
HB 13 1.53 (1.36-1.73) <0.001 0.002 2.33 (1.96-2.76) <0.001 0.234 1.58 (1.36-1.84) <0.001 0.007 1.67(1.52-1.83) <0.001 0.001 1.86(1.58-2.19) <0.001 0.612
PB 4 1.49 (1.06-2.092) 0.020 0.023 1.16 (0.35-3.80) 0.811 0.016 1.87 (1.40-2.49) <0.001 0.247 1.72(1.09-2.72) 0.019 0.073 0.88(0.30-2.54) 0.806 0.029
Cancer type
Liver cancer 4 1.66 (1.43-1.94) <0.001 0.714 2.15 (1.42-3.25) <0.001 0.312 2.03 (1.61-2.57) <0.001 0.847 2.06 (1.64-2.58) <0.001 0.963 1.52 (1.02-2.24) 0.037 0.220
Lung cancer 2 1.24 (0.63-2.41) 0.534 0.013 1.13 (0.13-9.50) 0.912 0.003 1.59 (1.11-2.29) 0.012 0.268 1.49 (0.77-2.89) 0.234 0.058 0.90 (0.14-5.90) 0.915 0.007
Breast cancer 2 1.51 (1.09-2.11) 0.014 0.058 2.41 (0.97-6.01) 0.059 0.075 1.49 (1.23-1.81) <0.001 0.187 1.55 (1.29-1.87) <0.001 0.101 1.64 (1.13-2.38) 0.009 0.116
GC 3 1.81 (1.58-2.07) <0.001 0.253 2.90 (2.16-3.90) <0.001 0.638 1.89 (1.56-2.29) <0.001 0.584 2.07 (1.73-2.48) 0.007 0.400 2.14 (1.62-2.84) <0.001 0.716
GIC 4 1.26 (0.97-1.65) 0.084 0.008 1.49 (0.77-2.88) 0.236 0.024 1.33 (1.03-1.73) 0.030 0.084 1.36 (1.00-1.84) 0.050 0.020 1.32 (0.76-2.30) 0.331 0.069
Others 4 1.39 (1.01-1.92) 0.043 0.020 2.32 (1.56-3.46) <0.001 0.257 1.26 (0.81-1.96) 0.316 0.020 1.39 (0.89-2.19) 0.150 0.011 2.10 (1.43-3.09) <0.001 0.546
Histopathologic differentiation   
poor 4 1.61 (0.96-2.70) 0.069 0.006 2.34 (0.64-8.59) 0.200 0.008 2.03 (1.10-3.75) 0.024 0.050 2.07 (1.05-4.12) 0.037 0.015 1.56 (0.62-3.95) 0.346 0.060
moderate 4 1.29 (0.96-1.72) 0.091 0.341 0.98 (0.44-2.20) 0.959 0.333 1.83 (1.23-2.74) 0.003 0.527 1.67 (1.13-2.47) 0.010 0.341 0.73 (0.33-1.59) 0.425 0.523
well 4 1.48 (0.88-2.50) 0.143 0.060 2.14 (0.53-8.60) 0.284 0.045 1.60 (1.00-2.55) 0.049 0.172 1.60 (1.03-2.50) 0.037 0.121 1.35 (0.67-2.73) 0.398 0.146
TNM stage
I-II 8 1.38 (1.04-1.84) 0.028 0.006 1.89 (0.89-4.00) 0.097 0.005 1.43 (1.16-1.77) 0.001 0.415 1.49 (1.22-1.82) <0.001 0.096 1.61 (0.81-3.18) 0.175 0.008
III-IV 8 1.56 (1.31-1.87) <0.001 0.032 2.23 (1.67-2.98) <0.001 0.075 1.79 (1.40-2.28) <0.001 0.047 1.86 (1.44-2.40) <0.001 0.017 1.70 (1.29-2.23) <0.001 0.276
  1. OR odds ratio, 95% CI 95% confidence interval, P Q p value for heterogeneity, HB hospital-based, PB population-based, GC Gynecological cancer, GIC Gastrointestinal cancer, TNM Tumor, Node, Metastasis.