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Table 2 Association between phenotype of high myopia and genetic variants at 15q14 and 15q25 in the Han Chinese Population

From: Association study of 15q14 and 15q25 with high myopia in the Han Chinese population

Chr/Mb

SNP [Minor Allele]

Case MAF

Allele Frequency

OR

P value

Adjusted P*

Genotype Frequency

OR

H-W P

15/35.0

rs634990[C]

0.483

C

T

   

CC

CT

TT

CC

CT

TT

 
 

HM cases

 

450(43.4%)

586(56.6%)

0.88(0.76-1.04)

0.27

0.54

102(19.7%)

246(47.5%)

170(32.8%)

0.82(0.63-1.07)

1.01(0.81-1.26)

1.15(0.91-1.45)

0.45

 

Controls

 

858(46.6%)

984(53.4%)

   

212(23.0%)

434(47.1%)

275(29.9%)

   

0.11

15/79.5

rs8027411[G]

0.441

G

T

   

GG

GT

TT

GG

GT

TT

 
 

HM cases

 

396(38.7%)

626(61.3%)

0.78(0.66-0.91)

0.006

0.012

77(15.1%)

242(47.4%)

192(37.6%)

0.66(0.50-0.89)

0.99(0.80-1.23)

1.32(1.06-1.66)

0.96

 

Controls

 

839(44.9%)

1029(55.1%)

   

197(21.1%)

445(47.6%)

292(31.3%)

   

0.26

  1. Adjusted P* is the P value modified by Bonferroni’s mutable tests correction.