Ancestral origins of ADME genes in African Americans. The examples of ancestral origins of three ADME core genes in African Americans: (A) ABCB1, (B) CYP3A4, (C) CYP1A2, where each box has 122 rows representing the diploid sequences of 61 individuals. Blue colored fragments mean originating from European, red means originating from Africa, and gray means unknown component. The start and end positions of genes are plotted at corresponding locations using green bars, and the up- and down-stream 100 kb regions are also included in the figures. (D) The percentage of local European genetic components in ASW for 32 ADME genes. The red bar at the bottom of panel represents the average percentage of European genetic components from the whole genome, while the error bars represent the SD of the percentages. Note that for CYP2E1, GSTM1, SULT1A1, UGT1A1, UGT2B15, ABCG2, SLC22A1, and SLCO1B1 the percentages are average values, while for the remaining genes they are consistent values (see Additional file 2: Figure S2).