Analysis of locus-specific differentiation of 32 ADME core genes. (A) The distribution of the F
loci and all sites located in 32 ADME core genes, including regions 10 kb up- and down-stream. In the figure, the dashed line represents the cutoff with an empirical P value of 0.01 (F
= 0.221). (B) The variant effect prediction of highly differentiated loci.