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Table 1 Summary information of highly differential functional SNPs at ADME core genes

From: Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for Pharmacogenomics

rsID Gene allele fASW fCEU fYRI He ASW He CEU He YRI Type Dataset Related
rs2032582 ABCB1 C/A 0.082 0.453 0.000 0.151 0.496 0.000 NON_SYNONYMOUS GKB amitriptyline, atorvastatin, etc.
rs2231164 ABCG2 C/T 0.287 0.912 0.188 0.409 0.161 0.305 INTRONIC GKB antineoplastic agents
rs2622628 ABCG2 C/A 0.443 0.012 0.494 0.493 0.023 0.500 INTRONIC GKB antiepileptics
rs2606345 CYP1A1 C/A 0.197 0.682 0.006 0.316 0.433 0.011 UPSTREAM GKB carbamazepine, phenobarbital, etc.
rs2472304 CYP1A2 C/T 0.131 0.659 0.000 0.228 0.450 0.000 SYNONYMOUS GKB caffeine, paroxetine
rs2470890 CYP1A2 G/A 0.139 0.659 0.011 0.240 0.450 0.023 INTRONIC GKB caffeine, paroxetine
rs2070673 CYP2E1 A/T 0.369 0.777 0.205 0.466 0.347 0.325 INTRONIC GKB cytarabine, ethambutol, etc.
rs12333983 CYP3A4 A/T 0.361 0.924 0.205 0.461 0.141 0.325 DOWNSTREAM GKB tacrolimus
rs3735451 CYP3A4 A/G 0.279 0.982 0.199 0.402 0.035 0.319 UPSTREAM GKB methadone
rs2242480 CYP3A4 T/C 0.303 0.947 0.142 0.423 0.100 0.244 INTRONIC GKB clopidogrel, warfarin, etc.
rs4646437 CYP3A4 C/A 0.353 0.982 0.256 0.456 0.035 0.381 INTRONIC GKB methadone, tacrolimus
rs2687116 CYP3A4 C/T 0.344 0.982 0.233 0.452 0.035 0.357 UPSTREAM GKB tacrolimus
rs2740574 CYP3A4 C/T 0.344 0.924 0.171 0.452 0.141 0.283 INTRONIC GKB carbamazepine, cyclophosphamide, etc.
rs1851426 CYP3A4 A/G 0.303 0.929 0.171 0.423 0.131 0.283 INTRONIC GKB tacrolimus
rs4646458 CYP3A5 G/A 0.418 0.947 0.278 0.487 0.100 0.402 3PRIME_UTR GKB tacrolimus
rs4646457 CYP3A5 C/A 0.328 0.947 0.159 0.441 0.100 0.268 DOWNSTREAM GKB tacrolimus
rs15524 CYP3A5 G/T 0.648 0.988 0.483 0.456 0.023 0.499 DOWNSTREAM GKB tacrolimus
rs7780328 CYP3A5 T/C 0.336 0.953 0.159 0.446 0.090 0.268 ESSENTIAL_SPLICE_SITE GKB alfentanil, alprazolam, etc.
rs776746 CYP3A5 G/A 0.426 0.959 0.301 0.489 0.079 0.421 INTRONIC RegulomeDB -
rs11101985 GSTM1 G/C 0.098 0.418 0.011 0.177 0.486 0.023 INTRONIC RegulomeDB -
rs4630 GSTT1 G/A 0.279 0.877 0.091 0.402 0.216 0.165 3PRIME_UTR GKB dexamethasone, paclitaxel, etc.
rs145334570 SLCO1B3 G/T 0.516 0.112 0.631 0.499 0.199 0.466 NON_SYNONYMOUS - -
rs4762683 SLCO1B3 T/C 0.516 0.112 0.631 0.499 0.199 0.466 SPLICE_SITE - -
rs3764009 SLCO1B3 C/T 0.484 0.888 0.369 0.499 0.199 0.466 SPLICE_SITE - -
rs7311358 SLCO1B3 G/A 0.484 0.888 0.369 0.499 0.199 0.466 NON_SYNONYMOUS GKB docetaxel, mycophenolate mofetil
rs7435827 UGT2B17 A/G 0.098 0.665 0.046 0.177 0.446 0.087 INTRONIC RegulomeDB -
rs7434408 UGT2B17 A/G 0.172 0.706 0.068 0.285 0.415 0.127 INTRONIC RegulomeDB -
rs74764812 UGT2B17 T/C 0.172 0.665 0.057 0.285 0.446 0.107 INTRONIC RegulomeDB -
  1. It is noted that in the column “allele”, the first allele is ancestral state, while the second one highlighted in bold is derived state.