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Table 2 Biologically plausible models of maternal-fetal genotype incompatibility

From: Entropy-based selection for maternal-fetal genotype incompatibility with application to preterm prelabor rupture of membranes

Model

GC

G m

G o

Scenario

1

M 1

AA

Aa

Mother has 1 more copy of allele A than the heterozygous offspring

2

M 2

Aa

AA

Offspring has 1 more copy of allele A than the heterozygous mother

3

M 3

Aa

aa

Mother has risk allele A that the offspring does not

4

M 4

aa

Aa

Offspring has risk allele A that the mother does not

5

M 1

AA

Aa

Mother-offspring pair has 3 copies of A allele

 

M 2

Aa

AA

 

6

M 1

AA

Aa

Mother has 1 more copy of A allele

 

M 3

Aa

aa

 

7

M 1

AA

Aa

Offspring has an allele that the mother does not

 

M 4

aa

Aa

 

8

M 2

Aa

AA

Mother has an allele that the offspring does not

 

M 3

Aa

aa

 

9

M 2

Aa

AA

Offspring has 1 more copy of the A allele

 

M 4

aa

Aa

 

10

M 3

Aa

aa

Mother-offspring pair possesses 3 copies of allele a

 

M 4

aa

Aa

 

11

M 1

AA

Aa

All possible mismatched maternal-fetal genotype combinations

 

M 2

Aa

AA

 
 

M 3

Aa

aa

 
 

M 4

aa

Aa

 
  1. A: Minor allele;
  2. GC: Genotype combination.