Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, −DQB1, and –DPB1

Table 3 **HIBAG model* two-field HLA allele imputation accuracy in the ACCESS African American gene-specific training sets by posterior probability threshold of the most likely genotype call**

	DRB1		DQB1		DPB1
Posterior probability range	N	Accuracy	N	Accuracy	N	Accuracy
>0.10	163	89.8	188	97.6	249	86.3
>0.20	160	90.3	187	97.6	239	87.9
>0.30	149	92.2	184	97.8	213	90.6
>0.40	136	94.4	175	98.9	174	95.4
>0.50	113	95.8	166	99.1	147	98.0
>0.60	93	97.3	156	99.4	121	97.9
>0.70	70	98.6	142	99.3	87	97.1
>0.80	53	98.1	116	99.1	38	96.1
>0.90	28	96.4	74	99.3	13	96.2

Abbreviations: N denotes, count; Accuracy, imputation accuracy.
*The models trained on the subset of ACCESS African Americans with training samples selected at random (from a total of 325) to match the number of subjects used to construct the published HIBAG African ancestry models: HLA-DRB1 (n = 161), HLA-DQB1 (n = 137), and HLA-DPB1 (n = 75).

ISSN: 2730-6844