Figure 1
Percentage of variants predicted to be pathogenic with four In silico tools prediction on variants present and not present in ESP database. Differences in proportions of variants predicted to be damaging for those variants present in ESP versus variants not present in ESP were assessed using Fisher’s exact test. *p = 4.1 × 10−10, **p = 2.8 × 10−11, ***p = 1.1 × 10−6, ****p = 4.5 × 10−5, *****p = 3.5 × 10−15.