Figure 4

Genetic differentiation between GIH and INS on chromosome 15. Evidence of genetic differentiation between GIH and INS on chromosome 15 between 45.5 Mb and 47.0 Mb from three discovery mechanisms that look for considerable regional differences in SNP allele frequencies (as quantified by the F_ST metric) relative to the genome (top panel); differential evidence of positive selection from iHS in GIH and INS (middle panel); XP-EHH signals contrasting GIH and INS that are found in either tails of the genome-wide distribution (bottom panel). In all three panels, SNPs exhibiting extreme evidence relative to the genome are displayed in differently in yellow, orange and red according to the respective percentiles as illustrated in the three figure legends. Genes located within this region are identified according to NCBI hg18 (build 36) coordinates.