Criteria | Discovery criterion | Validation criterion |
---|---|---|
F ST Region with an over-representation of SNPs possessing high FST values relative to the genome-wide distribution of FST scores | Regional evidence in the top 0.1% of the genome-wide distribution, in which: | Discovered region should contain evidence found in the top 1% of the genome-wide distribution |
- Regions are defined by window sizes of 100Â kb and 500Â kb; | Â | |
- Evidence is defined by the P-value of the exact Binomial test for the proportion of SNPs with FST in the top 1st percentile (100Â kb) or 0.1st percentile (500Â kb) respectively of the genome-wide distribution score | ||
Differential iHS signals for GIH and INS | At least one SNP with normalized iHS score in the top 0.19% of the genome-wide distribution in one population, but not present in the top 1% of the genome-wide distribution in the other population | At least one SNP in the discovered region should have an iHS score in the top 1% of the genome-wide distribution, but absent in the top 1% of genome-wide distribution of iHS scores in the second population |
XP-EHH between GIH and INS | Normalized XP-EHH scores should lie in the top 0.01% of the genome-wide distribution | At least one SNP in the discovered region should lie in the top 0.5% of the genome-wide distribution of the normalized XP-EHH scores |