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Table 3 Test for difference in proportion table for sequence sets divided by host organism.

From: Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence

 

Human

 

Nt = 313, NS31 = 151, NS31N = 161

 

AA+S31

AA+S31N

Favors

P-value

10L

1

2

NA

ID

10H

1

3

NA

ID

26F

2

2

NA

ID

27A

5

6

NA

0.42

27T

0

1

NA

ID

27S

0

0

NA

ID

27I

3

2

NA

ID

28I

11

74

S31N

<0.001

30T

0

0

NA

ID

34E

0

0

NA

ID

 

Swine

 

Nt = 277, NS31 = 145, NS31N = 131

 

AA+S31

AA+S31N

Favors

P-value

10L

1

5

NA

ID

10H

5

4

NA

ID

26F

0

4

NA

ID

27A

1

29

S31N

<0.001

27T

38

0

S31

<0.001

27S

2

0

NA

ID

27I

69

4

S31

<0.001

28I

6

111

S31N

<0.001

30T

0

0

NA

ID

34E

0

0

NA

ID

 

Other Hosts

 

Nt = 539, NS31 = 447, NS31N = 91

 

AA+S31

AA+S31N

Favors

P-value

10L

48

18

S31N

<0.01

10H

22

8

NA

0.21

26F

1

1

NA

ID

27A

8

4

NA

<0.001

27T

5

0

NA

ID

27S

0

0

NA

ID

27I

50

0

S31

<0.001

28I

274

22

S31

<0.001

30T

1

0

NA

ID

34E

0

0

NA

ID

  1. The amino acids of interest are included in the left column. The 'AA+S31' column is the count of amino acids in the left column that occur in conjunction with S31 (WT). The 'AA+S31N' column is the count of amino acids in the left column that occur in conjunction with S31N. The 'Favors' column indicates the amino acid, S31 or S31N, with which the amino acid in the left column occurs more often then expected, according the test for difference in proportions. The 'P-value' column gives the p-value of each test for difference in proportion. ID: insufficient data (<10 samples of the AA).