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Table 1 Histotype and staging parameters associated with the MMP phenotype in our GCsa

From: Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype

Variable

Number of patients

P valueb

 

Total (%)

MMP+ (%)

MMP-(%)

 

Histotype

    

   Intestinal

32(68.0)

12(37.5)

20(62.5)

 

   Diffuse + Mixed

15(32.0)

3(20.0)

12(80.0)

NSc

T (depth of wall infiltration)

    

   T1 + T2

12(25.5)

6(50.0)

6(50.0)

 

   T3 + T4

35(74.5)

9(25.7)

26(74.3)

NS

N (lymph node status)

    

   N0

18(38.3)

11(78.5)

7(21.5)

 

   N+

29(61.7)

4(12.1)

25(87.9)

= 0.001

M (metastases)

    

   M0

40(85.1)

14(35.0)

26(65.0)

 

   M+

7(14.9)

1(14.2)

6(85.8)

NS

Staging

    

   I + II

20(42.5)

10(58.8)

10(41.2)

 

   III + IV

27(57.5)

5(16.6)

22(83.4)

= 0.02

Totala

47

15

32

 
  1. a – data were available for 47 out of 50 cases b – at Fisher exact test c – NS = not statistically significant