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Table 2 Status of the coding microsatellites within BLM, WRN, RECQL, CBL, hMSH6, hMSH3,IGFIIR,TGF-βRII and BAX genes in the series of gastric carcinomas with microsatellite mutator phenotype.

From: Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype

Case

Histotypea

Stagingb

 

BLM

WRN

REQL

CBL

hMSH6

hMSH3

IGFIIR

TGF-βRII

BAX

No.

  

MSIc

(A)9

(A)8

(A)9

(ATG)6

(C)8

(A)8

(G)8

(A)10

(G)8

31R

I

I(T2N0M0)

2/5

-

-

-

-

-

-

-

-

-

57R

I

IV(T3N1M1)

5/5

-

-

-

-

-

-

-

+

-

63R

I

I(T2N0M0)

5/5

-

-

-

-

+

-

-

+

+

67R

I

I(T2N0M0)

4/5

-

-

-

-

-

-

-

+

-

69R

D

II(T3N0M0)

4/5

+

-

-

+

+

+

-

+

+

79R

I

I(T2N0M0)

5/5

-

-

-

-

-

-

-

-

-

3P

I

II(T3N0M0)

4/7

+

-

-

-

-

-

-

-

+

11P

I

III(T3N1M0)

3/7

+

-

-

-

-

+

+

+

-

14P

M

II(T3N0M0)

6/7

+

-

-

+

+

-

-

+

+

17P

I

II(T3N0M0)

3/7

-

-

-

-

-

-

-

-

-

19P

D

III(T3N1M0)

3/7

-

-

-

-

-

-

-

-

-

27P

I

IV(T4N0M0)

2/5

-

-

-

-

-

-

-

+

-

30P

I

I(T2N0M0)

3/6

-

-

-

-

-

-

-

-

-

37P

I

I(T2N0M0)

3/7

-

-

-

-

-

-

-

+

-

38P

I

III(T3N2M0)

3/7

-

-

-

-

-

-

-

+

-

%

present study (number of cases)

27%

0%

0%

13%

20%

13%

7%

60%

27%

mutations

   

(4/15)

(0/15)

(0/15)

(2/15)

(3/15)

(2/15)

(1/15)

(9/15)

(4/15)

 

reported in literature (in GCs)d

-

-

-

-

22–52%

19–64%

19–24%

42–83%

15–64%

  1. a – I = intestinal type; D = diffuse type; M = mixed type b – according to the TNM classification (Sobin and Wittekind, 1997) c – number of unstable / total tested microsatellites d – data compiled from the references: [17,27,42,50,51,52]