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Table 2 Status of the coding microsatellites within BLM, WRN, RECQL, CBL, hMSH6, hMSH3,IGFIIR,TGF-βRII and BAX genes in the series of gastric carcinomas with microsatellite mutator phenotype.

From: Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype

Case Histotypea Stagingb   BLM WRN REQL CBL hMSH6 hMSH3 IGFIIR TGF-βRII BAX
No.    MSIc (A)9 (A)8 (A)9 (ATG)6 (C)8 (A)8 (G)8 (A)10 (G)8
31R I I(T2N0M0) 2/5 - - - - - - - - -
57R I IV(T3N1M1) 5/5 - - - - - - - + -
63R I I(T2N0M0) 5/5 - - - - + - - + +
67R I I(T2N0M0) 4/5 - - - - - - - + -
69R D II(T3N0M0) 4/5 + - - + + + - + +
79R I I(T2N0M0) 5/5 - - - - - - - - -
3P I II(T3N0M0) 4/7 + - - - - - - - +
11P I III(T3N1M0) 3/7 + - - - - + + + -
14P M II(T3N0M0) 6/7 + - - + + - - + +
17P I II(T3N0M0) 3/7 - - - - - - - - -
19P D III(T3N1M0) 3/7 - - - - - - - - -
27P I IV(T4N0M0) 2/5 - - - - - - - + -
30P I I(T2N0M0) 3/6 - - - - - - - - -
37P I I(T2N0M0) 3/7 - - - - - - - + -
38P I III(T3N2M0) 3/7 - - - - - - - + -
% present study (number of cases) 27% 0% 0% 13% 20% 13% 7% 60% 27%
mutations     (4/15) (0/15) (0/15) (2/15) (3/15) (2/15) (1/15) (9/15) (4/15)
  reported in literature (in GCs)d - - - - 22–52% 19–64% 19–24% 42–83% 15–64%
  1. a – I = intestinal type; D = diffuse type; M = mixed type b – according to the TNM classification (Sobin and Wittekind, 1997) c – number of unstable / total tested microsatellites d – data compiled from the references: [17,27,42,50,51,52]