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Table 4 Published studies of FABP2 and A54T

From: The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians

Subjects/description

Genetic marker

Result*

Phenotype

Ref

   A. Sib-pair study

Non-diabetic Pima Indians

[4]

 

MNS red cell antigen

+

maximal insulin-stimulated glucose uptake

 
  

+

insulin action index

 
  

-

fasting insulin

 

Non-diabetic Pima Indians

[5]

 

ANX5

+

maximal insulin-stimulated glucose uptake

 
 

FABP2

+

maximal insulin-stimulated glucose uptake

 
  

+

fasting insulin

 

Non-diabetic Mexican Americans

[15]

 

FABP2

+

2-h post challenge insulin levels

 

Pondicherian Tamil Indians

[16]

 

A54T

-

diabetes, body mass index,

 
  

-

waist/hip ratio, insulinemia

 
  

-

glycemia, triglyceride, total cholesterol

 

French families with morbid obesity

[17]

 

FABP2

-

body mass index, adult life body with gain

 
   

fasting leptin, insulin, glycerol, free fatty acid

 

   B. Linkage study

Mexican American diabetic pedigrees

[18]

 

FABP2

-

diabetes

 

French diabetic pedigrees

[19]

 

FABP2

-

diabetes

 

Pedigrees with lipodystrophic diabetes

[20]

 

FABP2

-

lipodystrophic diabetes

 

French families with morbid obesity

[17]

 

FABP2

-

obesity

 

   C. Population association study

UK, Finnish and Welsh population

[21]

 

FABP2

-

diabetes/impaired glucose tolerance

 

Pima Indian population

[9]

 

A54T

-

diabetes

 

Japanese population

[22]

 

FABP2

-

diabetes/impaired glucose tolerance

 

Aboriginal Canadians population

[28]

 

A54T

-

diabetes

 

Canadian Inuit population

[26]

 

A54T

-

coronary artery disease

 

Diabetic and nondiabetic Finnish population

[27]

 

A54T

-

coronary artery disease

 

Japanese population

[23]

 

A54T

-

diabetes

 

Japanese population

[24]

 

A54T

-

diabetes, obesity, hypertension

 

African Americans population

[25]

 

A54T

-

diabetes

 

   D. Quantitative association study

Non-diabetic Pima Indians

[9]

 

A54T

+

fasting insulin, fasting fat oxidation

 
  

+

glucose uptake

 

Aboriginal Canadians

[13]

 

A54T

+

body mass index, percent body fat

 
  

+

fasting plasma triglyceride

 

Finnish non-diabetic and diabetic subjects

[31]

 

A54T

-

insulin sensitivity

 

Obese Finnish subjects

[32]

 

A54T

-

fatty acid composition

 

Japanese subjects without fasting hyperglycemia

[14]

 

A54T

+

2-hour post challenge insulin,

 
  

+

intraabdominal fat

 

Aboriginal Canadians

[36]

 

A54T

+

plasma triglyceride

 

Finnish patients with familial combined hyperlipidemia

[29]

 

A54T

+

lipid oxidation rate, HDL triglycerides,

 
  

+

LDL triglyceride

 
  

-

insulin sensitivity

 

Obese Finnish subjects

[33]

 

A54T

-

fasting insulin, glucose, lipid

 
  

-

lipoprotein, basal metabolic rate,

 
  

-

glucose and lipid oxidation

 

Japanese population

[23]

 

A54T

-

insulin sensitivity

 

Japanese population

[24]

 

A54T

-

dyslipidemia, hyperuricemia

 
  

-

hyperinsulinemia

 

Guadeloupe Indian population

[30]

 

A54T

+

triglyceride

 

American Caucasian population

**

 

A54T

+

insulin sensitivity (%S)

 

   E. Interventional study

Response to dietary fiber in Canadian subjects

[36]

 

A54T

+

greater decreases in total

 
  

+

LDL cholesterol and Apo-B

 

Postprandial lipemic response in normotriglyceridemic subjects

[35]

 

A54T

+

greater increases in chylomicron and VLDL triglycerides!

 
  1. * "+" denotes positive association or linkage and "-" denotes negative association or linkage; **the present study