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Table 4 Published studies of FABP2 and A54T

From: The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians

Subjects/description Genetic marker Result* Phenotype Ref
   A. Sib-pair study
Non-diabetic Pima Indians [4]
  MNS red cell antigen + maximal insulin-stimulated glucose uptake  
   + insulin action index  
   - fasting insulin  
Non-diabetic Pima Indians [5]
  ANX5 + maximal insulin-stimulated glucose uptake  
  FABP2 + maximal insulin-stimulated glucose uptake  
   + fasting insulin  
Non-diabetic Mexican Americans [15]
  FABP2 + 2-h post challenge insulin levels  
Pondicherian Tamil Indians [16]
  A54T - diabetes, body mass index,  
   - waist/hip ratio, insulinemia  
   - glycemia, triglyceride, total cholesterol  
French families with morbid obesity [17]
  FABP2 - body mass index, adult life body with gain  
    fasting leptin, insulin, glycerol, free fatty acid  
   B. Linkage study
Mexican American diabetic pedigrees [18]
  FABP2 - diabetes  
French diabetic pedigrees [19]
  FABP2 - diabetes  
Pedigrees with lipodystrophic diabetes [20]
  FABP2 - lipodystrophic diabetes  
French families with morbid obesity [17]
  FABP2 - obesity  
   C. Population association study
UK, Finnish and Welsh population [21]
  FABP2 - diabetes/impaired glucose tolerance  
Pima Indian population [9]
  A54T - diabetes  
Japanese population [22]
  FABP2 - diabetes/impaired glucose tolerance  
Aboriginal Canadians population [28]
  A54T - diabetes  
Canadian Inuit population [26]
  A54T - coronary artery disease  
Diabetic and nondiabetic Finnish population [27]
  A54T - coronary artery disease  
Japanese population [23]
  A54T - diabetes  
Japanese population [24]
  A54T - diabetes, obesity, hypertension  
African Americans population [25]
  A54T - diabetes  
   D. Quantitative association study
Non-diabetic Pima Indians [9]
  A54T + fasting insulin, fasting fat oxidation  
   + glucose uptake  
Aboriginal Canadians [13]
  A54T + body mass index, percent body fat  
   + fasting plasma triglyceride  
Finnish non-diabetic and diabetic subjects [31]
  A54T - insulin sensitivity  
Obese Finnish subjects [32]
  A54T - fatty acid composition  
Japanese subjects without fasting hyperglycemia [14]
  A54T + 2-hour post challenge insulin,  
   + intraabdominal fat  
Aboriginal Canadians [36]
  A54T + plasma triglyceride  
Finnish patients with familial combined hyperlipidemia [29]
  A54T + lipid oxidation rate, HDL triglycerides,  
   + LDL triglyceride  
   - insulin sensitivity  
Obese Finnish subjects [33]
  A54T - fasting insulin, glucose, lipid  
   - lipoprotein, basal metabolic rate,  
   - glucose and lipid oxidation  
Japanese population [23]
  A54T - insulin sensitivity  
Japanese population [24]
  A54T - dyslipidemia, hyperuricemia  
   - hyperinsulinemia  
Guadeloupe Indian population [30]
  A54T + triglyceride  
American Caucasian population **
  A54T + insulin sensitivity (%S)  
   E. Interventional study
Response to dietary fiber in Canadian subjects [36]
  A54T + greater decreases in total  
   + LDL cholesterol and Apo-B  
Postprandial lipemic response in normotriglyceridemic subjects [35]
  A54T + greater increases in chylomicron and VLDL triglycerides!  
  1. * "+" denotes positive association or linkage and "-" denotes negative association or linkage; **the present study