Chromosomal localisation and gene structure of the human TDH gene. (A) The human TDH gene is located at 8p23 and the neighbouring genes are: myotubularin related protein 8, MTMR8: acyl-malonyl condensing enzyme, AMAC: threonine dehydrogenase, TDH: hypothetical protein, C8orf13; B lymphoid tyrosine kinase, BLK. Genes encoded by + and - stands are shown above and below the line respectively. The telomeric and centromeric directions are indicated. (B) The human TDH gene spans 10 kb and consists of 8 exons. The putative initiation methionine codon, stop codon and poly-adenylation signal are shown. Closed boxes indicate the ORF and the sizes (in bp) of the exons and introns are indicated.