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Table 4 Mutations in exon 8 in UNC93A in tumours

From: The human homologue of unc-93 maps to chromosome 6q27 – characterisation and analysis in sporadic epithelial ovarian cancer

ALLELE LOSS
TUMOR AGE STAGE HISTOLOGY DIFF 149 297 193 264 MUTATION NORMAL
19 59 III Serous poorly NI NI + MI c.1159T>C, Y387H* c.1159T>C, Y387H*
          c.1208T>C, M403T c.1208T>C, M403T
          c.1225G>A, V409I*  
          c.1334T>C+1335C>G, V445A* c.1334T>C+1335C>G, V445A*
34 74 III Serous moderately + + NI NI c.1159T>C, Y387H * Identical to the tumour
          c.1208T>C, M403T  
          c.1334T>C+1335C>G, V445A*  
44 58 III Serous poorly NI NI - - c.1159T>C, Y387H * Identical to the tumour
          c.1208T>C, M403T  
          c.1225G>A, V409I *  
          c.1334T>C+1335C>G, V445A*  
49 44 Ic Serous moderately - NI - - c.1159T>C, Y387H * Identical to the tumour
          c.1208T>C, M403T  
          c.1208T>C+1209G>A*, M403T,  
          c.1334T>C+1335C>G, V445A*  
54 28 Ia Mucinous well NI NI NI - c.1159T>C, Y387H * Identical to the tumour
          c.1208T>C, M403T  
          c.1334T>C+1335C>G, V445A*  
  1. NI, not informative or unable to amplify; -, both alleles retained; +, LOH (loss of heterozygosity); MI, microsatellite instability. Data as previously published [16]. All mutations are homozygous except when indicated by *. Normal refers to matched DNA from peripheral blood.The location of each mutation in the cDNA sequence is based on numbering from the inititiator codon ATG.