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Table 5 Mutations in UNC93A in ovarian cancer cell lines

From: The human homologue of unc-93 maps to chromosome 6q27 – characterisation and analysis in sporadic epithelial ovarian cancer

CELL LINE EXON 1 EXON 3 EXON 4 EXON 5 EXON 6 EXON 8
41M - - - - c.874G>A, V292I * c.1159T>C, Y387H *
       c.1208T>C, M403T
       c.1208T>C+1209G>A*, M403T,
       c.1334T>C+1335C>G, V445A*
59M c.1-32T>Ga - - - c.874G>A, V292I * c.1159T>C, Y387H *
       c.1208T>C, M403T *
       c.1334T>C+1335C>G, V445A*
OAW28 - - - - c.874G>A, V292I * c.1159T>C, Y387H *
       c.1208T>C, M403T
       c.1334T>C+1335C>G, V445A*
       c.1159T>C, Y387H *
OAW42 c.1-32T>G c.452G>A, W151X * c.500-15T>Gb - c.874G>A, V292I * c.1208T>C, M403T
       c.1208T>C+1209G>A*, M403T,
       c.1334T>C+1335C>G, V445A*
PEO1 c.1-32T>G c.452G>A, W151X - - - c.1159T>C, Y387H *
       c.1208T>C, M403T
       c.1208T>C+1209G>A*, M403T,
       c.1334T>C+1335C>G, V445A*
      - c.1159T>C, Y387H *
PEO4 c.1-32T>G c c.452G>A, W151X - -   c.1208T>C, M403T
       c.1208T>C+1209G>A*, M403T,
       c.1334T>C+1335C>G, V445A*
SKOV3 c.1-32T>G c.452G>A, W151X* - - c.874G>A, V292I c.1159T>C, Y387H *
       c.1334T>C+1335C>G, V445A*
UCI-101 c.1-32T>G - - c.659C>TA220V* c.874G>A, V292I  
       c.1159T>C, Y387H *
       c.1208T>C+1209G>A*, M403T,
       c.1334T>C+1335C>G, V445A*
  1. a: 32 bases upstream of the 'ATG' site. b: 15 bases upstream of start of exon4. All mutations are homozygous except when indicated by an *. The location of each mutation in the cDNA sequence is based on numbering from the inititiator codon ATG.