Figure 1

Region of conserved synteny of human Chr2-13-14 and mouse prox Chr11 Orthologous genes of human and mouse and their positions on the respective physical map are shown except for Kiaa0570 and Kiaa0729, which could not be mapped with radiation hybrids. Mouse orthologs for ELP and PX19 are not located within the investigated region. Gene order of HCC8 and UGP2 is based on our STS/EST mapping and sequence analysis. Gene order between human and mouse is conserved in three sections; the proximal and distal sections show the same orientation whereas the central section is inverted between the two species. The central part of the figure including the inverted section is shown slightly enlarged. For orientation, positions of microsatellites D2S2225 and D2S147 (human) and D11Mit19, D11Mit294 and D11Mit343 (mouse) are indicated. Blue arrows show orientation and relative genomic sizes of genes, the arrowhead points to the 3' end. Yellow bars represent chromosomal regions covered by YAC or BAC contigs. Red overlays show sequenced sections (human: public draft sequence, mouse: BACs sequenced by our group, AC091422, AC091423, AC091424, AC091428, AC091419, AC091420, AC091421). Green bars indicate the genomic clones (YAC ymWIBR100H6, ^*; BAC 135B4, ^§), which cover Kiaa0903 and Hspc159. Approximate distances are given in Kb for human Chr2p13-14, in cM for mouse prox Chr11.