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Table 1 Characteristics of the Tayside Diabetic population by PPP1R3A genotype and sex. Parameters are given as corrected means ± Standard deviation, the corrected means are based on multiple measures through time and are adjusted for age diagnosed, age at which parameter was measured and drug treatment at time of measurement.

From: Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus

Male ARE1/1 ARE1/2 ARE2/2 p value
N 432 479 111  
Age Diagnosed (years) 56.5 ± 0.6 55.5 ± 0.5 †53.2 ± 1.1 0.008 (0.011*)
BMI (Kg/m 2 ) 29.9 ± 0.2 29.7 ± 0.2 29.9 ± 0.5 NS
GHB (%) 7.6 ± 0.05 7.5 ± 0.05 7.5 ± 0.1 NS
Female ARE1/1 ARE1/2 ARE2/2 p value
N 415 412 101  
Age Diagnosed (years) 56.7 ± 0.6 58.4 ± 0.6 †59.5 ± 1.2 0.038 (0.2*)
BMI (Kg/m 2 ) 31.6 ± 0.3 31.2 ± 0.3 30.3 ± 0.6 0.021
GHB (%) 7.8 ± 0.05 7.7 ± 0.05 7.5 ± 0.1 0.047
  1. * = p value after inclusion of BMI-at-diagnosis in the linear regression model. †p = 0.0001 for comparison between male and female ARE2 homozygotes (recessive model) p < 0.000001 for a comparison between male and female allele carriers (co-dominant model).