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Table 2 RHD alleles predicted from coding sequence polymorphism

From: RHD allele distribution in Africans of Mali

Allele

Nucleotide aberrations

Amino acid aberrations

Donors carrying the allele

Reference

RHD

None (reference sequence)

None

42

[20]

DAU-0

1136C > T

T379M

18

[9]

RHDΨ

RHDΨ †

M218I, F223V, S225F, Y269X

7

[5]

Ccdes

186G > T, 410C > T, 455A > C

L62F, A137V, N152T

5

[6]

DAU-0.1

579G > A, 1136C > T

T379M

2

This work

RHD(384T > C)

384T > C

None

1

This work

DMA/

621G > C

L207F

1

This work

DAU-3

835G > A, 1136C > T

V279M, T379M

1

[9]

  1. * The sum is less than 116 alleles, because homozygous occurrences were not accounted for. † All RHDΨ alleles detected carried the 37 bp duplication at the intron3/exon 4 junction and the five single nucleotide substitutions 609G > A, 654G > C,667T > G,674C > T, and 807T > G as previously described by Singleton et al. [5]. ‡ In three donors, the observed aberrations would also be compatible with the presence of the DIII type 4 allele, because normal RHD sequences occurred in trans.