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Table 3 Polymorphism in non-coding regions and haplotype association

From: RHD allele distribution in Africans of Mali

Polymorphism   Number of samples carrying a
DNA segment position Haplotype association double peak * single peak *
Intron 1 -28G > C DCe, Dce, DcE 14 9
Intron 6 28C > T RHDΨ ce 4 3
Exon 10, 3' UTR 1347A > G Dce 6 1
Intron 2 51C > T Ccdes§ 3 2
Intron 2 135A > G Ccdes§ 3 2
Intron 2 -26G > A Ccdes§ 3 2
Intron 2 36A > G Dce or DAU-0ce 1 0
Intron 5 12G > A DcE or RHD(384T > C)ce or Dce or RHD(384T > C)cE 1 0
Exon 10, 3' UTR 1377G > A Dce or DAU-0ce 1 0
  1. * The presence of a double peak in the electropherogram indicates another RHD allele in trans. A single peak may indicate the presence of an RHD deletion in trans, the homozygous presence of an allele with the given polymorphism, or – in case of intron 1 position -28 – the presence of Ccdesin trans. † -28G > C was present in all 13 DCe haplotypes, but only in 13 of 43 Dce and 1 of 8 DcE haplotypes. ‡ Present in all RHDΨ donors. § Present in all Ccdesdonors.