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Table 3 Polymorphism in non-coding regions and haplotype association

From: RHD allele distribution in Africans of Mali

Polymorphism

 

Number of samples carrying a

DNA segment

position

Haplotype association

double peak *

single peak *

Intron 1

-28G > C

DCe, Dce, DcE

14

9

Intron 6

28C > T

RHDΨ ce

4

3

Exon 10, 3' UTR

1347A > G

Dce

6

1

Intron 2

51C > T

Ccdes§

3

2

Intron 2

135A > G

Ccdes§

3

2

Intron 2

-26G > A

Ccdes§

3

2

Intron 2

36A > G

Dce or DAU-0ce

1

0

Intron 5

12G > A

DcE or RHD(384T > C)ce or Dce or RHD(384T > C)cE

1

0

Exon 10, 3' UTR

1377G > A

Dce or DAU-0ce

1

0

  1. * The presence of a double peak in the electropherogram indicates another RHD allele in trans. A single peak may indicate the presence of an RHD deletion in trans, the homozygous presence of an allele with the given polymorphism, or – in case of intron 1 position -28 – the presence of Ccdesin trans. † -28G > C was present in all 13 DCe haplotypes, but only in 13 of 43 Dce and 1 of 8 DcE haplotypes. ‡ Present in all RHDΨ donors. § Present in all Ccdesdonors.