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Table 1 CR2 and PIGR polymorphisms in NPC cases and control subjects.

From: Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer

  THAI CHINESE TOTAL
  case control case control case control
Number of tests 110 104 42 107 175 317
CR2IVS2-848C→T       
+/+ 0 1 1 1 2 2
+/- 34 20 7 21 48 63
-/- 76 83 34 85 125 252
+ allele frequency 0.15 0.11 0.11 0.11 0.15 0.11
Crude OR (95%CI) 1.55(0.84–2.85) 1.00(0.41–2.39) 1.48(0.98–2.22)1
Ethnic group adjusted OR (95%CI) 1.47(0.96–2.26)
age, sex and ethnic group adjusted OR (95%CI) 1.80(1.14–3.03)1
PIGR IVS3-156G→T       
+/+ 32 30 9 42 49 114
+/- 61 58 26 48 99 155
-/- 17 16 7 17 27 48
+ allele frequency 0.57 0.57 0.52 0.62 0.56 0.60
Crude OR (95%CI) 1.00(0.67–1.50) 0.68(0.40–1.17) 0.84(0.64–1.11)
Ethnic group adjusted OR (95%CI) 0.88(0.66–1.18)
Age, sex and ethnic group adjusted OR (95%CI) 0.93(0.67–1.29)
PIGR 1093G→A       
GG 53 48 17 52 79 142
GA 49 46 24 42 82 137
AA 8 10 1 13 14 38
G allele frequency 0.70 0.68 0.69 0.68 0.69 0.66
Crude OR (95%CI) 1.11(0.72–1.71) 1.04(0.58–1.86) 1.10(0.83–1.47)
Ethnic group adjusted OR (95%CI) 1.03(0.76–1.40)
Age, sex and ethnic group adjusted OR (95%CI) 0.96(0.68–1.36)
PIGR 1739C→T       
CC 79 58 32 60 132 170
CT 26 40 9 38 37 130
TT 5 6 1 9 6 17
C allele frequency 0.84 0.75 0.87 0.74 0.86 0.74
Crude OR (95%CI) 1.70(1.03–2.82)1 2.35(1.11–5.07)1 2.14(1.49–3.09)3
Ethnic group adjusted OR (95%CI) 2.26(1.51–3.25)3
Age, sex and ethnic group adjusted OR (95%CI) 2.06(1.36–3.30)2
  1. Total is Thai, Chinese and Thai-Chinese cases and controls. CR2 IVS2-848C→T and PIGR IVS3-156G→T allele+ and allele- are digested and not digested with the restriction enzyme, respectively. G and A are nucleotide at PIGR 1093, and C and T are nucleotide at PIGR 1739, respectively. OR (95%CI) = odd ratios and 95% confidence interval of allele CR2+, PIGR IVS3-156G, PIGR 1093G, PIGR 1739C when compared with the other alleles of the same SNPs. 1 p < 0.05, 2 p < 0.001, 3 p < 0.0001