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Table 1 CR2 and PIGR polymorphisms in NPC cases and control subjects.

From: Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer

 

THAI

CHINESE

TOTAL

 

case

control

case

control

case

control

Number of tests

110

104

42

107

175

317

CR2IVS2-848C→T

      

+/+

0

1

1

1

2

2

+/-

34

20

7

21

48

63

-/-

76

83

34

85

125

252

+ allele frequency

0.15

0.11

0.11

0.11

0.15

0.11

Crude OR (95%CI)

1.55(0.84–2.85)

1.00(0.41–2.39)

1.48(0.98–2.22)1

Ethnic group adjusted OR (95%CI)

1.47(0.96–2.26)

age, sex and ethnic group adjusted OR (95%CI)

1.80(1.14–3.03)1

PIGR IVS3-156G→T

      

+/+

32

30

9

42

49

114

+/-

61

58

26

48

99

155

-/-

17

16

7

17

27

48

+ allele frequency

0.57

0.57

0.52

0.62

0.56

0.60

Crude OR (95%CI)

1.00(0.67–1.50)

0.68(0.40–1.17)

0.84(0.64–1.11)

Ethnic group adjusted OR (95%CI)

0.88(0.66–1.18)

Age, sex and ethnic group adjusted OR (95%CI)

0.93(0.67–1.29)

PIGR 1093G→A

      

GG

53

48

17

52

79

142

GA

49

46

24

42

82

137

AA

8

10

1

13

14

38

G allele frequency

0.70

0.68

0.69

0.68

0.69

0.66

Crude OR (95%CI)

1.11(0.72–1.71)

1.04(0.58–1.86)

1.10(0.83–1.47)

Ethnic group adjusted OR (95%CI)

1.03(0.76–1.40)

Age, sex and ethnic group adjusted OR (95%CI)

0.96(0.68–1.36)

PIGR 1739C→T

      

CC

79

58

32

60

132

170

CT

26

40

9

38

37

130

TT

5

6

1

9

6

17

C allele frequency

0.84

0.75

0.87

0.74

0.86

0.74

Crude OR (95%CI)

1.70(1.03–2.82)1

2.35(1.11–5.07)1

2.14(1.49–3.09)3

Ethnic group adjusted OR (95%CI)

2.26(1.51–3.25)3

Age, sex and ethnic group adjusted OR (95%CI)

2.06(1.36–3.30)2

  1. Total is Thai, Chinese and Thai-Chinese cases and controls. CR2 IVS2-848C→T and PIGR IVS3-156G→T allele+ and allele- are digested and not digested with the restriction enzyme, respectively. G and A are nucleotide at PIGR 1093, and C and T are nucleotide at PIGR 1739, respectively. OR (95%CI) = odd ratios and 95% confidence interval of allele CR2+, PIGR IVS3-156G, PIGR 1093G, PIGR 1739C when compared with the other alleles of the same SNPs. 1 p < 0.05, 2 p < 0.001, 3 p < 0.0001