Haplotype

THAI

CHINESE

TOTAL

ETHNIC GROUP ADJUSTED



case

control

case

control

case

control
 

GC frequency

0.556169

0.525147

0.590097

0.447343

0.543478

0.451985
 
OR (95%CI)

1.13(0.76–1.68)

1.18(1.05–3.12)

1.37(1.04–1.79)

1.36(1.02–1.80)

GT frequency

0.148376

0.171968

0.100379

0.234900

0.043478

0.175374
 
OR (95%CI)

0.84(0.49–1.46)

0.35(0.14–0.80)

0.64(0.43–0.93)

0.55(0.37–0.84)

AC frequency

0.280194

0.224853

0.278951

0.286302

0.413043

0.283864
 
OR (95%CI)

1.34(0.85–2.13)

0.95(0.52–1.72)

1.23(0.91–1.66)

1.28(0.93–1.76)

AT frequency

0.015260

0.078032

0.030573

0.031455

0.000001

0.088777
 
OR (95%CI)

0.17(0.04–0.62)

1.10(0.22–4.85)

0.12(0.03–0.40)

0.26(0.09–0.63)

case vs case
 
0.085
     
case vs control

<0.05^{a}
 
<0.05^{b}
 
<0.005^{c}
  
control vs control
 
0.192
     
 Each haplotype frequency was calculated by the Estimating Haplotypefrequencies (EH) software program^{23}. Total is Thai, Chinese and ThaiChinese cases and controls. OR (95%CI) = odd ratios and 95% confidence interval between the tested haplotype and the other three alleles, The OR (95%CI) calculation used the estimated number from each haplotype number of cases and controls. The number of haplotypes in the total category were calculated from the summation of estimated haplotype number from each ethnic. GC, AC, GT, and AT are 1093G1739C, 1093A1739C, 1093G1739T, and 1093A1739T haplotypes, respectively. Case vs case = p value comparing haplotype frequency between Thai case and Chinese case. Case vs control = p value comparing haplotype frequency between case and control in each ethnic. a is Thai, b is Chinese and c is total. Control vs control = p value comparing haplotype frequency between Thai control and Chinese control.