Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples

Chien, Kuo-Liong; Hsu, Hsiu-Ching; Su, Ta-Chen; Yang, Chi-Yu; Lee, Yuan-Teh

doi:10.1186/1471-2156-4-7

Table 6 Logarithm triglyceride vs. HDL cholesterol ratio: Class D regressive models, conditional on proband phenotypes

From: Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples

I. Community-based:
Model	Sporadic		Pure familial correlation, i.e. polygenic		Environmental + familial correlation		Pure major gene (Mendel)		Mendel + familial correlation		Unrestricted, general
	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.
q_A	[1]		[1]		0.190	0.035	0.251	0.035	0.264	0.045	0.203	0.049
τ_AA	-		-		=q_A		[1]		[1]		0.266	0.144
τ_AB	-		-		=q_A		[0.5]		[0.5]		0.431	0.125
τ_BB	-		-		=q_A		[0]		[0]		0.044	0.073
μ_AA	0.864	0.024	0.903	0.043	2.450	0.170	2.363	0.162	2.316	0.196	2.514	0.227
μ_AB	=μ_AA		=μ_AA		1.281	0.082	1.149	0.074	0.971	0.165	1.326	0.130
μ_BB	=μ_AA		=μ_AA		0.555	0.057	0.560	0.035	0.651	0.095	0.554	0.075
σ²	0.400	0.021	0.465	0.038	0.239	0.029	0.209	0.016	0.276	0.040	0.202	0.027
ρ_MF	[0]		0.041	0.071	0.028	0.125	-0.026	0.106	0.062	0.106	0.058	0.138
ρ_MO	[0]		0.401	0.067	0.555	0.114	[0]		0.284	0.077	0.286	0.318
ρ_FO	[0]		0.184	0.068	0.394	0.101	[0]		0.150	0.134	0.212	0.154
ρ_SS	[0]		0.513	0.067	0.643	0.084	[0]		0.332	0.085	0.457	0.257
#	2		6		9		6		9		12
-2ln(L)	1372.22		1308.95		1260.71		1279.92		1266.27		1252.03
υ²	120.19		56.92		8.68		27.89		14.24
Degree of freedom	10		6		3		6		3
P value	0.000		0.000		0.034		0.000		0.003		Baseline
AIC	1376.22		1320.95		1278.71		1291.92		1284.27		1276.03
II. Hospital based,
Model	Sporadic		Pure familial correlation, i.e. polygenic		Environmental + familial correlation		Pure major gene (Mendel)		Mendel + familial correlation		Unrestricted, general
	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.	Parameter	S.E.
q_A	[1]		[1]		0.232	0.060	0.368	0.036	0.290	0.028	0.369	0.036
τ_AA	-		-		=q_A		[1]		[1]		0.598	0.277
τ_AB	-		-		=q_A		[0.5]		[0.5]		0.181	0.097
τ_BB	-		-		=q_A		[0]		[0]		0.756	0.099
μ_AA	0.801	0.019	0.801	0.020	1.997	0.125	1.751	0.077	1.953	0.098	1.727	0.062
μ_AB	=μ_AA		=μ_AA		1.215	0.134	0.396	0.016	0.289	0.040	0.396	0.014
μ_BB	=μ_AA		=μ_AA		0.443	0.076	0.945	0.029	1.036	0.032	0.944	0.020
σ²	0.459	0.018	0.458	0.018	0.246	0.031	0.259	0.018	0.211	0.023	0.251	0.018
ρ_MF	[0]		0.160	0.043	0.292	0.081	0.247	0.001	[0]		0.247	0.001
ρ_MO = ρ_FO = ρ_SS	[0]		0.320	0.072	0.579	0.090	0.735	0.000	[0]		0.735	0.000
#	2		4		7		7		5		10
-2ln(L)	2690.30		2662.03		2637.51		2637.78		2665.49		2625.11
Degree of freedom	8		6		3		3		5
P	0.000		0.000		0.000		0.006		0.005		Baseline
AIC	2694.3		2670.03		2651.51		2651.78		2675.49		2645.11

Abbreviation: #, number of parameters; SEM, standard error of mean; q_A, gene frequency; τ_AA, τ_AB, τ_BB, transmission probability; μ_AA, μ_AB, μ_BB, genotype means; σ², variance; ρ_MF, ρ_MO, ρ_FO, ρ_SS, correlation coefficients among spouse, mother-offspring, father-offspring and sibling pairs; #, number of parameters; ln(L), logarithm of likelihood; AIC, Akaike information criteria; P, significance level compared with the unrestricted general model.

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