Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure

Table 1 Single and summary measures RHE linkage p-values (one-sided) for IBD allele sharing (SAGE/SIBPAL)^A

Chr	Gene (cM)^B	Marker (cM)^B	First SBP	Last SBP	Mean SBP	ΔSBP	Reg SBP
True positive results ( p < 0.001) at markers linked to SBP genes
13	Gb35 (85.2)	*ATA26D07*(90.8)	0.0002	0.04	0.001	0.88	0.94
21	Gs12 (29.5)	*GATA129D11*(26.6)	0.02	0.0008	0.004	0.11	0.0009
		*ATA27F01*(40.0)	0.0005	0.0002	0.00005	0.003	0.006
	Gs10 (53.6)	*GATA188F04*(44.9)	0.001	0.00001	0.00001	0.005	0.0007
		*GATA70B08*(63.4)	0.06	0.0002	0.002	0.002	0.001
False negative results ( p > 0.001) at markers near SBP genes
5	Gb34 (176.1)	*GATA6E05*(174.6)	0.008	0.28	0.09	0.42	0.21
7	Gb36 (47.5)	GGAA3F06 (45.2)	0.43	0.47	0.44	0.32	0.39
		GATA13G11 (54.6)	0.47	0.84	0.74	0.27	0.51
15	Gs11 (4.5)	*GATA88H02*(13.2)	0.01	0.01	0.009	0.50	0.034
False positives ( p < 0.001) at markers with no linkage to SBP genes
2	-	*GATA4G12*(237.5)	0.0007	0.004	0.003	0.04	0.10
9	-	*GATA21A06*(24.2)	0.0008	0.15	0.01	0.95	0.84
17	-	*ATA43A10*(96.4)	0.80	0.045	0.31	0.02	0.0008

^ARHE models (SAGE/SIBPAL) employed GLS methods with adjustment for familiar correlation. ^BPositions (cM) correspond to Haldane sex-average map.

ISSN: 2730-6844