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Table 2 Misclassification rates of the simulated (Replication 1) Cohort 1 models predicting hypertension at visit 1.

From: Screening the genome to detect an association with hypertension

ModelA

Number of End-nodes

Cohort 1 Observed Error

Cohort 1 Cross-validation

Cohort 1 Model applied to Cohort 2

1) No Splits

1

6.4%

6.4%

7.9%

2) All M & E

3

5.5%

6.6%

10.1%

3) All M

3

5.5%

6.6%

10.1%

4) All E, subset of M

3

5.5%

6.6%

10.1%

5) All E, handpicked M

1

6.4%

6.4%

7.9%

  1. A1) no splits; 2) all allelic markers and environmental factors; 3) all allelic markers; 4) all environmental factors but only those allelic markers that occur at least 1% of the time or less than 99% of the time; and 5) all environmental factors but only those allelic markers that occur near the region of the underlying disease genes. All models shown have a complexity parameter of 5%.