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Table 2 Number of main haplotypes observed within genes compared to the number of possible haplotypes and yin yang haplotype distribution

From: Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

Gene Chromosome location No. of SNPs Kb spanned SNP density (kb/SNP) Observed No. of haplotypesa Expected No. of haplotypes Yin Yang haplotypesb
ApoE 19q13.2 4 3 0.75 6 16 GATC, CGTC
COL1A1 17q21.3-q22 3 16 5.33 4 8 GGG, GTG
ER-α 6q25.1 7 291 41.57 20 128 TCGCGGG, CTGCGGG
LEPR 1p31.2 3 66 22 7 8 GCG, GGA
PTHR1 3p22-p21.1 4 9 2.25 7 16 GTAA, ACGC
TGF-β1 19q13.1 3 22 7.33 4 8 C+C, T+C-
UCP3 11q13.4 3 5 1.67 4 8 TCT, CTC
VDR 12q12-14 4 39 9.75 12 16 GTGT, GTAC
  1. a: Only haplotypes with frequencies more than 1% were included [14] b: For the PTHR1 and UCP3, Yin yang haplotypes were presented. For the other six genes, the two most common haplotypes were presented. The haplotypes were reconstructed based on the SNPs in the order from 5' to 3' on the chromosome within each gene.