Table 1 Characteristics of study participants by genotype for PONS1 Q192R polymorphism (N = 3,266)

Dichotomous variables

Myocardial infarction (MI)

[53] 3.2 (2.4, 4.3)

[46] 3.5 (2.6, 4.8)

[12] 4.4 (2.3, 7.6)

0.51

Angina (but no history of MI)

[186] 11.1 (9.7, 12.8)

[165] 12.4 (10.7, 14.3)

[18] 6.6 (4.0, 10.3)

0.13

Any CHD (MI or angina)

[239] 14.3 (12.7, 16.1)

[211] 15.9 (14.1, 18.0)

[30] 11.1 (7.6, 15.4)

0.14

Diabetes at baseline

[75] 4.5 (3.6, 5.6)

[70] 5.3 (4.3, 6.7)

[12] 4.4 (2.5, 7.6)

0.61

Current smoker

[189] 11.3 (9.9, 12.9)

[163] 12.3 (10.6, 14.1)

[22] 8.1 (5.4, 11.9)

0.12

Ever smoker

[746] 44.6 (42.2, 47.0)

[596] 44.9 (42.3, 47.6)

[116] 42.9 (37.1, 48.8)

0.82

Adult manual social class

[964] 57.8 (55.4, 60.2)

[725] 54.7 (52.0, 57.3)

[157] 57.9 (51.9, 63.6)

0.20

Childhood manual social class

[1334] 79.9 (77.9, 81.8)

[1075] 81.1 (78.9, 83.1)

[219] 81.0 (75.9, 85.2)

0.72

On statin

[126] 7.5 (6.4, 8.9)

[95] 6.9 (5.6, 8.3)

[25] 9.2 (6.3, 13.2)

0.41

Continuous variables

Age

68.8 (68.6, 69.1)

68.8 (68.5, 69.1)

68.9 (68.3, 68.3)

0.91

HOMA^c

1.64 (1.59, 1.70)

1.72 (1.66, 1.79)

1.69 (1.56, 1.82)

0.15

Total cholesterol

6.64 (6.58, 6.70)

6.65 (6.58, 6.72)

6.61 (6.46, 6.75)

0.85

HDLc

1.65 (1.63, 1.67)

1.65 (1.63, 1.68)

1.70 (1.65, 1.76)

0.18

LDLc

4.15 (4.09, 4.20)

4.15 (4.09, 4.21)

4.02 (3.89, 4.16)

0.21

Triglycerides^c

1.67 (1.64, 1.71)

1.69 (1.65, 1.73)

1.71 (1.62, 1.81)

0.73

Systolic BP

148.3 (147.1, 149.5)

146.0 (144.6, 147.3)

150.4 (147.4, 153.4)

0.006

Diastolic BP

79.9 (79.3, 80.4)

78.9 (78.3, 79.6)

80.3 (78.9, 81.8)

0.05

BMI

27.6 (27.3, 27.8)

27.6 (27.4, 27.9)

27.6 (27.0, 28.2)

0.96

WHR

0.817 (0.814, 0.821)

0.821 (0.817, 0.824)

0.826 (0.818, 0.834)

0.11