Table 2 OSA results with nominally significant lod score increases in covariate-based subgroup (p ≤ 0.05). Significant results after correcting for testing multiple covariates on the same chromosome are shown in bold (p ≤ 0.05/8 = 0.006). "Max LOD" denotes maximum lod score in covariate-based subgroup of families identified by OSA. Baseline lod score in entire data set is difference between "Max LOD" and "Change from Baseline" columns. See text for covariate abbreviations.
| Â | Â | Â | Â | 62 families: 2+ sampled relatives with early or late AMD | 45 families: 2+ sampled relatives with late AMD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Chrom. | Kosambi cM | Nearest marker(s) | Variable and rank order | Max LOD | Change from baseline | P-value | No. of families in subset | Max LOD | Change from baseline | P-value | No. of families in subset |
2 | 87 | D2S441 | BMI Ascending | 2.2 | 2.1 | 0.03 | 20 | - | - | >0.05 | - |
6 | 90 | D6S1031 | BMI Descending | 1.6 | 1.6 | 0.0004 | 8 | - | - | >0.05 | - |
9 | 129 | D9S934 | IOP Descending | 1.7 | 1.2 | 0.05 | 42 | - | - | >0.05 | - |
12 | 50 | D12S1042 | PKYRS Descending | 1.5 | 1.5 | 0.04 | 12 | - | - | >0.05 | - |
14 | 33 | D14S608, D14S599 | IOP Ascending | 3.2 | 2.9 | 0.002 | 28 | - | - | >0.05 | - |
15 | 106 | D15S657 | IOP Ascending | 1.6 | 1.6 | 0.05 | 7 | - | - | >0.05 | - |
16 | 39 | D16S403 | IOP Descending | 2.3 | 1.7 | 0.04 | 35 | 2.9 | 2.1 | 0.008 | 32 |
| Â | 44 | D16S403 | SBP Descending | 2.2 | 2.0 | 0.04 | 6 | 2.3 | 1.7 | 0.05 | 25 |
| Â | 44 | D16S403 | BMI Descending | - | - | >0.05 | - | 2.0 | 1.4 | 0.04 | 9 |
17 | 11 | D17S1298 | PKYRS Descending | 1.5 | 1.3 | 0.03 | 14 | - | - | >0.05 | - |
20 | 67 | D20S481 | PKYRS Ascending | 1.9 | 1.5 | 0.03 | 26 | - | - | >0.05 | - |
21 | 40 | D21S2055 | DBP Descending | 1.6 | 1.6 | 0.04 | 11 | - | - | >0.05 | - |