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Table 1 The presence of Ndrg1 and HIF-1α proteins in various normal and malignant human tissues

From: Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers

TISSUE (n)

Ndrg1

HIF-1α

 

-

+

++

+++

-

+

++

+++

Normal Lung (30)

24

6

-

-

4

11

15

-

Lung Cancer (30)

-

-

3

27

-

6

21

3

Normal Liver (20)

7

13

-

-

2

15

3

-

Liver Cancer (20)

-

-

4

16

-

11

2

7

Normal Breast (18)

3

13

2

-

1

9

8

-

Breast Cancer (20)

-

-

6

14

-

4

7

9

Smooth Muscle (30)

12

15

3

-

9

11

10

-

S.M. Cancer (24)

-

6

7

11

-

9

12

3

Normal Brain (28)

24

4

-

-

18

10

-

-

Brain Cancer (36)

-

-

11

25

-

-

15

21

Normal Kidney (15)

-

6

8

1

-

5

10

-

Kidney Cancer (22)

-

-

7

15

-

7

9

6

Normal Skin (20)

14

6

-

-

11

9

-

-

Melanoma (10)

-

-

-

10

4

6

-

-

  1. Tissues were stained immunohistochemically with antibodies against Ndrg1 and HIF-1α as described in 'Methods' section. Each value shown in the table is from a single tissue sample from an individual patient. The numbers in parentheses (n) represent the total numbers of tissues stained with both antibodies. The expression levels were marked as follows: (-) no staining; (+) weak; (++) moderate; (+++) overexpression.