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Table 1 The presence of Ndrg1 and HIF-1α proteins in various normal and malignant human tissues

From: Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers

TISSUE (n) Ndrg1 HIF-1α
  - + ++ +++ - + ++ +++
Normal Lung (30) 24 6 - - 4 11 15 -
Lung Cancer (30) - - 3 27 - 6 21 3
Normal Liver (20) 7 13 - - 2 15 3 -
Liver Cancer (20) - - 4 16 - 11 2 7
Normal Breast (18) 3 13 2 - 1 9 8 -
Breast Cancer (20) - - 6 14 - 4 7 9
Smooth Muscle (30) 12 15 3 - 9 11 10 -
S.M. Cancer (24) - 6 7 11 - 9 12 3
Normal Brain (28) 24 4 - - 18 10 - -
Brain Cancer (36) - - 11 25 - - 15 21
Normal Kidney (15) - 6 8 1 - 5 10 -
Kidney Cancer (22) - - 7 15 - 7 9 6
Normal Skin (20) 14 6 - - 11 9 - -
Melanoma (10) - - - 10 4 6 - -
  1. Tissues were stained immunohistochemically with antibodies against Ndrg1 and HIF-1α as described in 'Methods' section. Each value shown in the table is from a single tissue sample from an individual patient. The numbers in parentheses (n) represent the total numbers of tissues stained with both antibodies. The expression levels were marked as follows: (-) no staining; (+) weak; (++) moderate; (+++) overexpression.