Figure 3

Comparison of Magel2 and Ndn expression patterns in the E10.5 and E12.5 mouse embryo. Comparison of Magel2 (A, C, E, G) and Ndn (B, D, F, H) RNA expression in E10.5 (A, B, C, D) and E12.5 (E, F) mouse embryos on adjacent sagittal sections, and in E12.5 (G, H) mouse embryos on adjacent transversal sections. In the E10.5 embryo, the predominant expression in the ventral parts of the neural tube is particularly evident (A, B, C, D) for both genes. Magel2 and Ndn display a strikingly similar profile of expression in the infundibulum recess (C, D). Asterics indicate expression of both genes in symetrical ventral stripes of cells in the neural tube (A, B). Note that Magel2 as Ndn are expressed in the mandibular component of the first branchial arch (C, D), in the tongue (E, F). In the E12.5 embryo, Magel2 and Ndn are expressed in identical structures such as the ganglionic eminence, the pons, the medulla oblongata, in the preplate of the telencephalic vesicle, the hypothalamus, the ventral thalamus, the zona limitans intrathalamica and in the basal plate (E, F, G, H). drg, dorsal root ganglia; ge, ganglionic eminence; hp, hypothalamus; mcba, mandibular component of the first branchial arch; mo, medulla oblongata; pp, telencephalic epithelium pre-plate; ps, pons; rp, rathke pouc;h so, somites; tg, tongue; vt, ventral thalamus; zi, zona limitans intrathalamica.