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Table 5 Size at 3 years, and growth from birth, by offspring H19 2992 genotype, (ALSPAC cohort)

From: Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans

Offspring genotype

CC

CT

TT

PA

PD

 

(n = 946)

(n = 462)

(n = 41)

  

Weight at 3 y (kg)

15.0 ± 1.7

14.9 ± 1.7

14.8 ± 1.7

0.4

0.4

Height at 3 y (cm)

95.6 ± 3.6

95.3 ± 3.5

95.2 ± 3.7

0.2

0.2

Change in Weight SDS 0–3 y

0.01 ± 1.17

-0.13 ± 1.07

-0.10 ± 1.29

0.01

0.02

Change in Height SDS 0–3 y

0.06 ± 1.12

-0.10 ± 1.02

-0.17 ± 1.26

0.01

0.01

  1. Mean ± SD, adjusted for sex and age
  2. PA = P value for additive genetic model (per T allele)
  3. PD = P value for dominant genetic model (CC versus T/*)