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Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.

From: Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10

 

B6 Background

Mixed Background

Cftr

Observed

Expected

Observed

Expected

+/+

240

201

57

52

+/-

431

403

115

104

-/-

134

201

36

52

P

<0.00001 (0.01612)*

 

0.03749

 
  1. Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.