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Table 1 Polymorphisms within the canine MLPH gene

From: Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

position1

cDNA position2

Doberman Pinscher

German Pinscher

157354 (exon 1)

-139 (5'-UTR)

G/T

G

157471 (exon 1)

-22 (5'-UTR)

A/G

A/G3

157486 (intron 1)

 

A/C3

A

163882 (intron 1)

 

C/T

T

163889 (intron 1)

 

A/C

C

163936 (intron 1)

 

A/G

A

163983 (intron 1)

 

A/G

A

164012 (intron 1)

 

A/G

A

164049 (intron 1)

 

A/G

A

164075 (intron 1)

 

C/T

C

164258 (exon 2)

+106

C/T (silent)

C

164397 (intron 2)

 

A/G

A

180908 (exon 3)

+223

A/G (75M/75V)

A

180994 (exon 3)

+309

C/T (silent)

C

180998 (exon 3)

+313

A/G (105N/105D)

A

183047 (intron 4)

 

C/G

G

183254 (exon 5)

+461

C/T (154T/154M)

C/T3 (154T/154M)

183336 (intron 5)

 

C/T

C/T3

184650 (intron 5)

 

C/T

T

184751 (exon 6)

+553

A/G (185S/185G)

G

184818 (intron 6)

 

A/G

G

186072 (intron 6)

 

C

T

186091 (intron 6)

 

C

T

186184 (exon 7)

+596

A/G3 (199H/199R)

A/G (199H/199R)

186329 (intron 7)

 

A

G

187449..54 (ex. 8) 4

+775 – +780

indel GAGGAT +/- (indel 259E260D)

indel GAGGAG +/-3 (indel 259E260E)

189560 (intron 8)

 

A/G

G

189575 (intron 8)

 

A

A/C

189719 (exon 9)

+1032

C/T (silent)

C

189728 (exon 9)

+1041

G

A/G (silent)

195548 (intron 9)

 

A/G

G

195720 (exon 10)

+1148

G (383G)

A (383D)

195808 (exon 10)

+1236

A (silent)

G (silent)

195888 (intron 10)

 

A/G

G

195891 (intron 10)

 

C/G

G

195900 (intron 10)

 

A/G

A/G

195901 (intron 10)

 

indel G +/-

indel G -

195932 (intron 10)

 

A/G

G

196097 (exon 11)

+1263

A/G (silent)

G

196354 (intron 11)

 

C/T

C

197343 (intron 11)

 

C/T

T

197510 (intron 11)

 

C/T

C

197673 (intron 12)

 

C/T

C

197730 (intron 12)

 

A/G

G

198080 (intron 12)

 

A

A/G

198126 (intron 12)

 

A/G

A/G

199847 (intron 13)

 

A/G

A

202837 (exon 16)

+1801 (3'-UTR)

C/T

C/T

  1. 1 Positions refer to the entire determined genomic sequence of 212.696 bp [EMBL:BN000728].
  2. 2 +1 corresponds to the adenosine of the translation start codon in the MLPH cDNA.
  3. 3 These polymorphisms were not present in the 11 samples of the initial mutation analysis. They were identified in additionally sequenced Pinscher samples.
  4. 4 Note that there are three alleles at this site (GAGGAG, GAGGAT, : : : : : :).