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Table 2 Genotype frequency of two MLPH polymorphisms in different breeds

From: Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

Breed and phenotype

No. of animals

dilute genotype1

Exon 22

Exon 7

   

CC3

CT

TT

199R199R

199R199H

199H199H

Doberman Pinscher (all)

140

 

50 (36%)

69 (49%)

21 (15%)

82 (59%)

47 (34%)

11 (8%)

   wildtype coat color

98

D.

50 (51%)

48 (49%)

-

62 (63%)

33 (34%)

3 (3%)

   wildtype coat color

21

Dd

-

21 (100%)

-

9 (43%)

12 (57%)

-

   dilute coat color

21

dd

-

-

21 (100%)

11 (52%)

2 (10%)

8 (38%)

Doberman Pinscher (American origin)

38

 

6 (16%)

21 (55%)

11 (29%)

35 (92%)

3 (8%)

-

   wildtype coat color

19

D.

6 (32%)

13 (68%)

-

16 (84%)

3 (16%)

-

   wildtype coat color

8

Dd

-

8 (100%)

-

8 (100%)

-

-

   dilute coat color

11

dd

-

-

11 (100%)

11 (100%)

-

-

Doberman Pinscher (European origin)

102

 

44 (43%)

48 (47%)

10 (10%)

   

   wildtype coat color

79

D.

44 (56%)

35 (44%)

-

46 (58%)

30 (38%)

3 (4%)

   wildtype coat color

13

Dd

-

13 (100%)

-

1 (8%)

12 (92%)

-

   dilute coat color

10

dd

-

-

10 (100%)

-

2 (20%)

8 (80%)

German Pinscher

143

 

143 (100%)

-

-

64 (45%)

61 (43%)

18 (13%)

   wildtype coat color

117

D.

117 (100%)

-

-

64 (55%)

53 (45%)

-

   wildtype coat color

8

Dd

8 (100%)

-

-

-

8 (100%)

-

   dilute coat color

18

dd

18 (100%)

-

-

-

-

18 (100%)

Beagle

6

 

1

3

2

1

3

2

   wildtype coat color

2

D.

1

1

 

1

1

 

   wildtype coat color

2

Dd

 

2

  

2

 

   dilute coat color

2

dd

  

2

  

2

Large Munsterlander

12

 

-

8

4

-

7

5

   wildtype coat color

8

Dd

-

8

-

-

7

1

   dilute coat color & BHFD

4

dd

-

-

4

-

-

4

Weimeraner (dilute coat color)

1

dd

 

1

  

1

 

Am. Staffordshire (dilute col. & CDA)

1

dd

 

1

  

1

 

Mountain Dogs

26

D.

25

1

 

25

1

 

Breeds unspecified

12

D.

10

2

 

9

3

 

total

341

 

229 (67%)

85 (25%)

27 (8%)

181 (53%)

124 (36%)

36 (11%)

  1. 1 A dog with wildtype coat color has the dilute genotype DD or Dd. If the animal has never produced any dilute (dd) offspring, the genotype can not be deduced unambiguously from the phenotype and the genotype is then denoted "D.". Among the Pinschers with wildtype coat colors there were also obligate carriers of the dilute allele (Dd), as these animals had dilute (dd) progeny.
  2. 2 This polymorphism corresponds to the silent C/T SNP in exon 2 at position 164258 in the reference sequence [EMBL:BN000728].
  3. 3 The following associations were highly significant in Pinscher breeds under Fisher's Exact Test (p < 0.001): Exon 2 for all Doberman Pinschers, American Doberman Pinschers, and European Doberman Pinschers; exon 7 for European Doberman Pinschers and for German Pinschers. Non-Pinscher breeds were not evaluated statistically because of their small sample numbers.
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BMC Genomic Data

ISSN: 2730-6844

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