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Table 2 Significance of Egfr polymorphisms on central region shape in NC, CA and Kenyan samples

From: Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology

    

Effect and significancec

Frequency of rare allele

Site

Significance in NC

Locationa

Typeb

CA

KI

NC

CA

K

C6085G

7.98 × 107

E1

R

(OK) ns

(Rev) ns

15/125

13/75

4/27

T30200C

6.11 × 1010

P2

N

(Rev) ns

(OK) ***

26/121

21/76

8/17

A31442T

5.49 × 108

I2

N

(OK) ns

(OK) ns

13/92

3/24

2/20

A36644T

9.60 × 107

I2

N

(Rev) ns

(OK) *

26/116

3/20

9/24

A36761C

5.17 × 106

I2

N

na

na

35/84

na

na

Del37192d

3.44 × 105

I2

N

(OK) ns

(OK) ns

8/106

10/77

7/24

A37282G

9.95 × 106

I2

N

nd

nd

13/106

1/77

0/23

T39160C

2.10 × 105

E4

S

(OK) ns

(OK) #

41/128

26/76

16/35

In39534d

8.81 × 105

I5

N

(OK) ns

(OK) ns

27/110

6/27

3/33

C40620Te

7.37 × 107

E6

S

(OK) ns

(OK) #

46/123

19/79

7/36

G42242A

8.88 × 105

3' UTR

N

nd

nd

5/105

1/12

1/25

  1. a. Location within the Egfr locus, where P2 refers to the second promoter and the other indicators to the respective introns (I), exons (E) and the 3'UTR.
  2. b. Type indicates the nature of the polymorphism; R: replacement, N: non-coding and S: synonymous.
  3. c. Effects of the polymorphisms in the same direction as in NC are indicated by "OK" and those in the reverse direction are designated by "Rev", with the significance of the genotypic term indicated. "ns": not significant, "#:" 0.1 > p > 0.05. "*": p > 0.01, "**": p > 0.001, "***": p > 0.0001. P-values are not adjusted to correct for the number of tests conducted. "na": genotypes not available, "nd": not computed because of allele rarity.
  4. d. Del37192 is a one base pair deletion and In39534 a four base insert (AACC repeated).
  5. e. Site C40620T is the same as site 8697 described by Dworkin et al. [21].
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BMC Genomic Data

ISSN: 2730-6844

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