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Table 2 Significance of Egfr polymorphisms on central region shape in NC, CA and Kenyan samples

From: Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology

     Effect and significancec Frequency of rare allele
Site Significance in NC Locationa Typeb CA KI NC CA K
C6085G 7.98 × 107 E1 R (OK) ns (Rev) ns 15/125 13/75 4/27
T30200C 6.11 × 1010 P2 N (Rev) ns (OK) *** 26/121 21/76 8/17
A31442T 5.49 × 108 I2 N (OK) ns (OK) ns 13/92 3/24 2/20
A36644T 9.60 × 107 I2 N (Rev) ns (OK) * 26/116 3/20 9/24
A36761C 5.17 × 106 I2 N na na 35/84 na na
Del37192d 3.44 × 105 I2 N (OK) ns (OK) ns 8/106 10/77 7/24
A37282G 9.95 × 106 I2 N nd nd 13/106 1/77 0/23
T39160C 2.10 × 105 E4 S (OK) ns (OK) # 41/128 26/76 16/35
In39534d 8.81 × 105 I5 N (OK) ns (OK) ns 27/110 6/27 3/33
C40620Te 7.37 × 107 E6 S (OK) ns (OK) # 46/123 19/79 7/36
G42242A 8.88 × 105 3' UTR N nd nd 5/105 1/12 1/25
  1. a. Location within the Egfr locus, where P2 refers to the second promoter and the other indicators to the respective introns (I), exons (E) and the 3'UTR.
  2. b. Type indicates the nature of the polymorphism; R: replacement, N: non-coding and S: synonymous.
  3. c. Effects of the polymorphisms in the same direction as in NC are indicated by "OK" and those in the reverse direction are designated by "Rev", with the significance of the genotypic term indicated. "ns": not significant, "#:" 0.1 > p > 0.05. "*": p > 0.01, "**": p > 0.001, "***": p > 0.0001. P-values are not adjusted to correct for the number of tests conducted. "na": genotypes not available, "nd": not computed because of allele rarity.
  4. d. Del37192 is a one base pair deletion and In39534 a four base insert (AACC repeated).
  5. e. Site C40620T is the same as site 8697 described by Dworkin et al. [21].