Table 1 NOD mouse Idd loci, location of their human orthologous regions, and selected functional candidate genes.
Idd | Mouse chromosome | Interval size (Mb) | Number of genes | Functional candidate genes in mouse Idd intervals | Location of human orthologous region | Human orthologue genes | Known gene function and previously reported disease associations |
|---|---|---|---|---|---|---|---|
Idd5.2 | 1 | 1.7 | 47 | Idd5.2: Nramp1/Slc11a1 | 2q35 | NRAMP1/SLC11A1 | Endosomal/lysosomal acidification and associated with protection from infectious disease and susceptibility to autoimmune disease |
Idd9.2 | 4 | 1.1 | 13 | Idd9.2: Frap1 | 1p32 | FRAP1 | FKBP12-rapamycin associated protein of mTOR. Candidate tumour suppressor gene, whose function in apoptosis is influenced by allelic variation |
Idd9.3 | 4 | 1.2 | 13 | Idd9.3: 4-1bb | 1p36 | 4-1BB | Role in enhancing and regulating CD4+, CD8+ T cells and dendritic cells |
Idd10 | 3 | 0.95 | 7 | Idd10: Cd101 | 1p12 | CD101 | Co-stimulatory receptor of T cells |
Idd13 | 2 | 6 cM | > 50* | Idd13: B2m | 15q21 | B2M | Required for antigen presentation by MHC class I molecules and the development of diabetes in NOD mice |
Idd18 | 3 | 0.7 | 2 | Idd18: Vav3 | 1p13-p21 | VAV3 | Guanine nucleotide exchange factor involved in signalling of T and B cell receptors |