Skip to main content

Table 1 NOD mouse Idd loci, location of their human orthologous regions, and selected functional candidate genes.

From: Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Idd Mouse chromosome Interval size (Mb) Number of genes Functional candidate genes in mouse Idd intervals Location of human orthologous region Human orthologue genes Known gene function and previously reported disease associations
Idd5.2 1 1.7 47 Idd5.2: Nramp1/Slc11a1 2q35 NRAMP1/SLC11A1 Endosomal/lysosomal acidification and associated with protection from infectious disease and susceptibility to autoimmune disease
Idd9.2 4 1.1 13 Idd9.2: Frap1 1p32 FRAP1 FKBP12-rapamycin associated protein of mTOR. Candidate tumour suppressor gene, whose function in apoptosis is influenced by allelic variation
Idd9.3 4 1.2 13 Idd9.3: 4-1bb 1p36 4-1BB Role in enhancing and regulating CD4+, CD8+ T cells and dendritic cells
Idd10 3 0.95 7 Idd10: Cd101 1p12 CD101 Co-stimulatory receptor of T cells
Idd13 2 6 cM > 50* Idd13: B2m 15q21 B2M Required for antigen presentation by MHC class I molecules and the development of diabetes in NOD mice
Idd18 3 0.7 2 Idd18: Vav3 1p13-p21 VAV3 Guanine nucleotide exchange factor involved in signalling of T and B cell receptors
  1. *Estimated number of genes. A version of this table is provided in Additional file 1 with the supporting published references (see Additional file 1).