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Table 3 Study design. Lengths of re-sequenced genomic regions, and number of tag SNPs or single SNPs genotyped in a pragmatic two-step genotyping design for NRAMP1, 4-1BB, FRAP1, CD101, B2M, and VAV3.

From: Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Locus Re-sequenced region (kb) n common SNPs* n tag SNPs Genotyping strategy (step 1 → step 2)
NRAMP1 12.13 12 4 Case-control → Family set 1+2
4-1BB 13.66 8 DIL4279/ss23142250 Family set 1
    DIL4277/rs226476  
    DIL4569/rs226478  
    DIL4274/ss23142263  
    DIL4570/ss23142264  
    DIL4571/rs679563  
    DIL4273/ss23142265  
    DIL4272/ss23142270  
FRAP1 30.88 21 6 Family set 1
CD101 15.9 18 8 Family set 1
B2M 9.33 10 8 Case-control → Family set 1
VAV3 27.69 19 (block 1) 18 (block 2) 15 (block 3) 7 (block 1) 11 (block 2) 10 (block 3) Family set 1
  1. *For the selection of tag SNPs, minor allele frequencies of 0.03 were used for 4-1BB, CD101 and FRAP1, and 0.05 for NRAMP1, B2M and VAV3. Note that the numbers of attempted and actual genotypes are given in Additional file 8. n, number.