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Table 5 Association analysis of non-synonymous SNPs. SNPs with allele frequencies above 0.05 and the NRAMP1 (GT)n microsatellite in up to 1,476 families with at least one affected offspring. N, number; T, number of transmissions; NT, number of untransmitted alleles; %T, percentage transmission of minor allele from heterozygous parents to type 1 diabetes offspring (obtained by transmission/disequilibrium test (TDT)); GTRR, genotype relative risk; P, probability value (two-sided).

From: Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Locus

Marker ID

Amino acid change/ alleles

Minor allele frequency

N families

T

NT

%T

P TDT

P GTRR

VAV3

DIL1521

Thr293Ser/T>A

0.27

1 476

834

840

49.64

0.77

0.90

 

DIL3809

Pro611Ser/G>A

0.13

1 476

417

429

49.29

0.68

0.84

CD101

DIL3794

Asn225Ser/A>G

0.32

652

517

515

49.9

0.95

0.96

NRAMP1

(GT)n

-

-

1 476

-

-

-

-

0.36