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Table 5 Association analysis of non-synonymous SNPs. SNPs with allele frequencies above 0.05 and the NRAMP1 (GT)n microsatellite in up to 1,476 families with at least one affected offspring. N, number; T, number of transmissions; NT, number of untransmitted alleles; %T, percentage transmission of minor allele from heterozygous parents to type 1 diabetes offspring (obtained by transmission/disequilibrium test (TDT)); GTRR, genotype relative risk; P, probability value (two-sided).

From: Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Locus Marker ID Amino acid change/ alleles Minor allele frequency N families T NT %T P TDT P GTRR
VAV3 DIL1521 Thr293Ser/T>A 0.27 1 476 834 840 49.64 0.77 0.90
  DIL3809 Pro611Ser/G>A 0.13 1 476 417 429 49.29 0.68 0.84
CD101 DIL3794 Asn225Ser/A>G 0.32 652 517 515 49.9 0.95 0.96
NRAMP1 (GT)n - - 1 476 - - - - 0.36