Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype

Table 3 Genotype-phenotype relationships for subclinical traits

Trait	Loci involved	Inheritance of trait
Unaffected individuals
a	D1 + D3	dominant, 30% penetrance
b	D1	dominant, 30% penetrance
c	D4	dominant, 15% penetrance
d	D3	dominant, 18% penetrance
e	D2	dominant, 19% penetrance
f	D2	dominant, 19% penetrance
g	D4	dominant, 15% penetrance
h	D2	dominant, 20% penetrance
i	none	random, 30% probability
j	none	random, 30% probability
k	D2 + D4	one disease allele at each locus, 30% penetrance
l	D4	recessive, 30% penetrance
Affected individuals
Phenotype 1	D1 + D2	have traits b, e, f, h
Phenotype 2	D2 + D3, D3 + D4	c, d, e, f, g, h
Phenotype 3	D1 + D4, D2 + D3	b, c, d, e, f, g, h
a	D1 + D3	dominant, 100% penetrance
i	none	random, 30% probability
j	none	random, 30% probability
k	D2 + D4	one disease allele at each locus, 30% penetrance
l	D4	recessive, 30% penetrance

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