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Table 3 Genotype-phenotype relationships for subclinical traits

From: Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype

Trait Loci involved Inheritance of trait
Unaffected individuals   
a D1 + D3 dominant, 30% penetrance
b D1 dominant, 30% penetrance
c D4 dominant, 15% penetrance
d D3 dominant, 18% penetrance
e D2 dominant, 19% penetrance
f D2 dominant, 19% penetrance
g D4 dominant, 15% penetrance
h D2 dominant, 20% penetrance
i none random, 30% probability
j none random, 30% probability
k D2 + D4 one disease allele at each locus, 30% penetrance
l D4 recessive, 30% penetrance
Affected individuals   
Phenotype 1 D1 + D2 have traits b, e, f, h
Phenotype 2 D2 + D3, D3 + D4 c, d, e, f, g, h
Phenotype 3 D1 + D4, D2 + D3 b, c, d, e, f, g, h
a D1 + D3 dominant, 100% penetrance
i none random, 30% probability
j none random, 30% probability
k D2 + D4 one disease allele at each locus, 30% penetrance
l D4 recessive, 30% penetrance