Table 1 Suggestive linkages region detected by RP model
From: Recursive partitioning models for linkage in COGA data
Marker name (DECODE) | NPL -log10 (p-value) | Overall RP -log10 (p-value) | Splitting covariates (in split order) | Subgroup with largest likelihood ratio | λ1 and λ2 for this subgroup | Bootstrap proportion (first split)a |
|---|---|---|---|---|---|---|
D2S2275 (Chr 2: 175.4 cM) | 0.31 | 3.47 | Ethnicity, Smoking | Not (both White non-Hispanic) | 4.35, 15.79 | 14% (53%) |
GABRB1 (Chr 4: 51.4 cM) | 0.35 | 4.81 | Sex, Age at onset | Both male; both early age at onset | 0.20, 0.94 | 19% (59%) |
D6S495 (Chr 6: 153.8 cM) | 1.19 | 3.85 | Smokers, Max drinks | One smokes, one not; one heavy drinker, one not | 8.00, 5.40 | 19% (47%) |
D14s51 (Chr 14: 111.0 cM) | 0.043 | 3.14 | Max drinks, Sex | One heavy drinker, one not | 0.38, 0.01 | 35% (52%) |
D20S50 (Chr 20: 13.6 cM) | 0.003 | 3.20 | Sex, Smoking | Both male; both smoker or both not smokers | 0.29, 0.07 | 25%(54%) |