Figure 2

Alcian blue staining of deparaffinised sections of jejunum (A, B, C, magnification ×200) and ileum (D, E, F, magnification ×400) from wild type MF1 (A, D) and mutant F₂₈ CF/1-Cftr^{TgH(neoim)Hgu}(B, E) and F₂₇ CF/3-Cftr^{TgH(neoim)Hgu}(C, F) animals showed focal hypertrophy of goblet cells in the ileum of the two inbred Cftr^{TgH(neoim)Hgu}mutant mice. Goblet cell counts are given as percentage of all epithelial cells. From each strain two mice and three sections/mouse were counted. Goblet cell count: CF/1 = 22.7% ± 2.3 (p = 0.112, p-value CF/1 compared to MF1), CF/3 = 23% ± 2.8 (p = 0.172, p-value CF/3 compared to MF1), MF1 = 16.8% ± 1.2. The jejunal sections of the same mice did not show any signs of goblet cell hypertrophy and were similar to wild type MF1 (Goblet cell count: CF/1 = 7.4% ± 0.4 (p = 0.18, p-value CF/1 compared to MF1), CF/3 = 8.5% ± 1.2 (p = 0.77, p-value CF/3 compared to MF1), MF1 = 8.8% ± 0.7.