Table 1 Cftr mRNA expression in CF/1-CftrTgH(neoim)Hguand CF/3-CftrTgH(neoim)Hgumice
From: Spontaneous rescue from cystic fibrosis in a mouse model
Log (molecules Cftr mRNA)/μg RNA | wild-type/total Cftr mRNA [%] | ||
|---|---|---|---|
Total Cftr mRNAa | wild-type Cftr mRNAb | ||
F8 – F10 CF/1-CftrTgH(neoim)Hgu(n = 10) | |||
Lung | 4.7 ± 0.3 | 3.6 ± 0.3 | 7.9 ± 2.1 |
Intestine | 5.1 ± 0.2 | 4.0 ± 0.2 | 7.1 ± 1.6 |
F18 CF/1-CftrTgH(neoim)Hgumice (n = 6) | |||
Lung | 4.5 ± 0.3 | 2.9 ± 0.6 | 2.7 ± 1.9 |
Intestine | 5.3 ± 0.2 | 4.0 ± 0.2 | 5.3 ± 1.3 |
F10 CF/3-CftrTgH(neoim)Hgumouse (n = 1) | |||
Lung | 4.5 | 3.1 | 4 |
Intestine | 5.0 | 3.6 | 4 |
F18 CF/3-CftrTgH(neoim)Hgumice (n = 6) | |||
Lung | 4.9 ± 0.2 | < 2 | << 0.1 |
Intestine | 5.1 ± 0.2 | 3.0 ± 0.5 | 0.8 ± 0.5 |
Ztm:MF1 mice (positive control, n = 4) | |||
Lung | 5.1 ± 0.2 | 5.1 ± 0.2 | |
Intestine | 5.3 ± 0.1 | 5.3 ± 0.1 | |